Associations of dietary cholesterol and fat, blood lipids, and risk for dementia in older women vary by APOE genotype
Dunk MM, Li J, Liu S, Casanova R, Chen JC, Espeland MA, Hayden KM, Manson JE, Rapp SR, Shadyab AH, Snetselaar LG, Van Horn L, Wild R, Driscoll I
Alzheimer's & dementia : the journal of the Alzheimer's Association · 42 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Health and Human Services
- Government
- Women's Health Initiative
- University or hospital
- University of Wisconsin-Milwaukee
- Government
- National Institutes of Health
- Government
- National Institute on Aging
- Government
- National Heart, Lung, and Blood Institute
- Government
- NIA NIH HHS
- Government
- NHLBI NIH HHS
- Grants
- National Institute on Aging (R01AG074345); National Heart, Lung, and Blood Institute (HHSN268201600018C); National Institute on Aging (HHSN-271-2011-00004C,); National Heart, Lung, and Blood Institute (HHSN268201600004C); National Heart, Lung, and Blood Institute (HHSN268201600001C); National Heart, Lung, and Blood Institute (HHSN271201100004C); National Institute on Aging (P30 AG072947); U.S. Department of Health and Human Services (HHSN-271-2011-00004C); National Institute on Aging (RF1 AG079149); National Institute on Aging (RF1 AG074345); National Heart, Lung, and Blood Institute (HHSN268201600003C); National Heart, Lung, and Blood Institute (HHSN268201600002C)
Based on 8 listed funder(s).
Publication
- Published
- 2023-07-12 · Alzheimers Dement · vol. 19 · issue 12 · pp. 5742–5754
- Publisher
- Wiley
- Cited
- 51 citations · more than 98% of similar papers · 6.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 52 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Alzheimer's disease research and treatments · Nutritional Studies and Diet · Dementia and Cognitive Impairment Research
- Keywords
- Dementia, Apolipoprotein E, Mendelian randomization, Internal medicine, Cholesterol, Odds ratio, Blood lipids, Lipoprotein, Endocrinology, Medicine, Risk factor, Gerontology, Biology, Disease, Genotype, Biochemistry
- MeSH
- humans, dementia, cholesterol, cholesterol, dietary, triglycerides, apolipoproteins e, risk factors, genotype, aged, female, apolipoprotein e4
14 authors
From SE, US, CN
- Michelle M. DunkKarolinska Institutet; University of Wisconsin–Milwaukee
- Jie LiRhode Island Department of Health; Brown University; Guangdong Academy of Medical Sciences; Guangdong Provincial People's Hospital
- Simin LiuRhode Island Department of Health; Brown University
- Ramon CasanovaWake Forest University
- Jiu‐Chiuan ChenUniversity of Southern California
- Mark Andrew EspelandWake Forest University
Abstract
Introduction
Whether apolipoprotein E's (APOE's) involvement in lipid metabolism contributes to Alzheimer's disease (AD) risk remains unknown.
Methods
Incident probable dementia and cognitive impairment (probable dementia+mild cognitive impairment) were analyzed in relation to baseline serum lipids (total, low-density lipoprotein [LDL], high-density lipoprotein [HDL], non-HDL cholesterol, total-to-HDL, LDL-to-HDL, remnant cholesterol, and triglycerides) using Mendelian randomization in 5358 postmenopausal women from the Women's Health Initiative Memory Study. We also examined associations of baseline dietary cholesterol and fat with lipids based on APOE status.
Results
After an average of 11.13 years, less favorable lipid levels related to greater dementia and cognitive impairment risk. Dementia (odds ratio [OR] = 3.13; 95% confidence interval [CI]: 2.31 to 4.24) and cognitive impairment (OR = 2.38; 95% CI: 1.85 to 3.06) risk were greatest in relation to higher remnant cholesterol levels. Greater cholesterol consumption related to poorer lipids in APOE4+ compared to APOE3 carriers.
Discussion
APOE4+ carriers consuming more cholesterol had less favorable lipids, which were associated with greater dementia and cognitive impairment risk.
Highlights
Less favorable serum lipids were associated with higher dementia incidence. Mendelian randomization findings suggest causality between lipids and dementia. Lipid levels in older women may be clinical indicators of dementia risk. APOE4 carriers had poorest lipid profiles in relation to cholesterol consumption. APOE risk for dementia may be modifiable through lipid management.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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