Ashwagandha (Withania somnifera) and Shunthi (Zingiber officinale) in mild and moderate COVID-19: An open-label randomized controlled exploratory trial
Singh H, Yadav B, Rai AK, Srivastava S, Saiprasad A, Jameela S, Singhal R, Muralidharan S, Mohan R, Chaudhary S, Rana R, Khanduri S, Sharma BS, Chandrasekhararao B, Srikanth N, Dhiman KS
Complementary therapies in medicine · 8 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2023-07-22 · Complement Ther Med · vol. 76 · p. 102966
- Publisher
- Elsevier BV
- Cited
- 17 citations · more than 95% of similar papers · 5.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 53 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Phytochemicals and Medicinal Plants · Andrographolide Research and Applications · Piperaceae Chemical and Biological Studies
- Keywords
- Withania somnifera, Medicine, Zingiber officinale, Adverse effect, Randomized controlled trial, Coronavirus disease 2019 (COVID-19), Traditional medicine, Internal medicine, Clinical trial, Alternative medicine, Disease, Pathology
- MeSH
- humans, withania, immunoglobulin g, plant extracts, treatment outcome, pandemics, biomarkers, covid-19, zingiber officinale
16 authors
From IN
- Harbans SinghCentral Council for Research in Ayurvedic Science
- Babita YadavCentral Council for Research in Ayurvedic Science
- Amit K. Rai · correspondingCentral Council for Research in Ayurvedic Science
- Sumit Kumar SrivastavaGovernment Ayurvedic College and Hospital
- A.J.V. Saiprasad
- Sophia JameelaCentral Council for Research in Ayurvedic Science
Abstract
Background
Ayurveda interventions have been used for prophylaxis and care during the COVID-19 pandemic in India and have shown promising results in promoting early clinical recovery from COVID-19.
Objective
To assess the efficacy and safety of Ashwagandha [Withania somnifera (L.) Dunal] tablet and Shunthi (Zingiber officinale Roscoe) capsule in mild and moderate COVID-19 compared to conventional standard care.
Methods
A randomized controlled exploratory trial was conducted at a designated COVID-19 care center in India with 60 participants having mild or moderate COVID-19. Ashwagandha, two tablets (250 mg each), and Shunthi, two capsules (500 mg each) twice daily for 15 days, were given orally to the participants in the Ayurveda group (AG) and the control group (CG) received conventional standard care. The outcome measures included clinical recovery rate, the proportion of participants with negative RT-PCR assay for COVID-19 on day 7 and day 15, mean time to attain clinical recovery, change in pro-inflammatory markers, serum IgG for COVID-19, HRCT chest findings, disease progression and incidence of adverse events (AE).
Results
A total of 60 participants were enrolled, and the data of 48 participants (AG = 25 and CG = 23) were considered for the statistical analysis. The mean time for clinical recovery was reduced by almost 50 % in the AG (6.9 days) compared to CG (13.0 days) (p < 0.001). The proportion of participants who attained viral clearance in AG was 76.0 % compared to 60.8 % in the CG (RR= 1.24, 95 % CI: 0.841, 1.851, p-value = 0.270). Changes in the pro-inflammatory markers, serum IgG for COVID-19, and HRCT chest findings were comparable in both groups, and no AE or disease progression was reported.
Conclusions
The Ayurveda interventions, Ashwagandha and Shunthi, can effectively reduce the duration of clinical recovery and improve time for viral clearance in mild and moderate COVID-19. These interventions were observed to be safe and well-tolerated during the duration of the trial.
Trial registration
Clinical Trial Registry of India - CTRI/2020/08/027224.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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