Longitudinal Changes in Choroidal Structure Following Repeated Low-Level Red-Light Therapy for Myopia Control: Secondary Analysis of a Randomized Controlled Trial
Xuan M, Zhu Z, Jiang Y, Wang W, Zhang J, Xiong R, Shi D, Bulloch G, Zeng J, He M
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) · 28 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2023-07-01 · Asia Pac J Ophthalmol (Phila) · vol. 12 · issue 4 · pp. 377–383
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 36 citations · more than 97% of similar papers · 5.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 63 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Ophthalmology and Visual Impairment Studies · Retinal Diseases and Treatments · Retinopathy of Prematurity Studies
- Keywords
- Randomized controlled trial, Medicine, Ophthalmology, Surgery
- MeSH
- choroid, humans, myopia, tomography, optical coherence, phototherapy, light, child
10 authors
From CN, AU
- Meng Xuan · correspondingSun Yat-sen University
- Zhuoting Zhu · correspondingSun Yat-sen University; The University of Melbourne; Centre for Eye Research Australia
- Yu Jiang · correspondingSun Yat-sen University
- Wei Wang · correspondingSun Yat-sen University
- Jiän Zhang · correspondingSun Yat-sen University
- Ruilin Xiong · correspondingSun Yat-sen University
Abstract
Purpose
Repeated low-level red-light (RLRL) therapy has been confirmed as a novel intervention for myopia control in children. This study aims to investigate longitudinal changes in choroidal structure in myopic children following 12-month RLRL treatment.
Materials and methods
The current study is a secondary analysis from a multicenter, randomized controlled trial (NCT04073238). Choroidal parameters were derived from baseline and follow-up swept-source optical coherence tomography scans taken at 1, 3, 6, and 12 months. These parameters included the luminal area (LA), stromal area (SA), total choroidal area (TCA; a combination of LA and SA), and choroidal vascularity index (CVI; ratio of LA to TCA), which were automatically measured by a validated custom choroidal structure assessment tool.
Results
A total of 143 children (88.3% of all participants) with sufficient image quality were included in the analysis (n=67 in the RLRL and n=76 in the control groups). At the 12-month visit, all choroidal parameters increased in the RLRL group, with changes from baseline of 11.70×10 3 μm 2 (95% CI: 4.14-19.26×10 3 μm 2 ), 3.92×10 3 μm 2 (95% CI: 0.56-7.27×10 3 μm 2 ), 15.61×10 3 μm 2 (95% CI: 5.02-26.20×10 3 μm 2 ), and 0.21% (95% CI: -0.09% to 0.51%) for LA, SA, TCA, and CVI, respectively, whereas these parameters reduced in the control group.
Conclusions
Following RLRL therapy, the choroidal thickening was found to be accompanied by increases in both the vessel LA and SA, with the increase in LA being greater than that of SA. In the control group, with myopia progression, both the LA and SA decreased over time.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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