Increased dietary intake of ultraprocessed foods and mitochondrial metabolism alterations in pediatric obesity
Coppola S, Paparo L, Trinchese G, Rivieri AM, Masino A, De Giovanni Di Santa Severina AF, Cerulo M, Escolino M, Turco A, Esposito C, Mollica MP, Berni Canani R
Scientific reports · 14 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Università degli Studi di Napoli Federico II
- Government
- European Commission
- Grants
- European Commission (PE00000003); European Commission (CUP D93C22000890001)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2023-08-03 · Sci Rep · vol. 13 · issue 1 · p. 12609
- Publisher
- Nature Portfolio
- Cited
- 20 citations · more than 95% of similar papers · 4.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 47 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Consumer Attitudes and Food Labeling · Advanced Glycation End Products research · Nutritional Studies and Diet
- Keywords
- Obesity, Medicine, Internal medicine, Endocrinology, Physiology, Peripheral blood mononuclear cell, Glycation, Ornithine, Mitochondrion, Biology, Diabetes mellitus, Biochemistry, In vitro, Amino acid
- MeSH
- leukocytes, mononuclear, humans, lysine, eating, child, pediatric obesity, glycation end products, advanced
12 authors
From IT
- Serena CoppolaFederico II University Hospital; CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)
- Lorella PaparoFederico II University Hospital; CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)
- Giovanna TrincheseFederico II University Hospital
- Andrea Margarita RivieriFederico II University Hospital
- Antonio MasinoFederico II University Hospital; CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)
- Anna Fiorenza de Giovanni di Santa SeverinaFederico II University Hospital; CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)
Abstract
The increased intake of ultraprocessed foods (UPFs) in the pediatric age paralleled with the risen prevalence of childhood obesity. The Ultraprocessed Foods in Obesity (UFO) Project aimed at investigating the potential mechanisms for the effects of UPFs in facilitating pediatric obesity, focusing on the direct role of advanced glycation end-products (AGEs) on mitochondrial function, the key regulator of obesity pathophysiology. We comparatively investigated the daily dietary intake of UPFs, energy, nutrients, dietary AGEs [Nε -(carboxymethyl)lysine (CML), Nε -(1-carboxyethyl)lysine (CEL), and Nδ -(5-hydro-5- methyl-4-imidazolon-2-yl)-ornithine (MG-H1)] in 53 obese patients and in 100 healthy controls visiting the Tertiary Center for Pediatric Nutrition of the Department of Translational Medical Science at the University of Naples "Federico II". AGEs skin accumulation and mitochondrial function in peripheral blood mononuclear cells (PBMCs) were also assessed. A higher intake of UPFs and AGEs, energy, protein, fat, and saturated fatty acids was observed in obese patients. Obese children presented significantly higher skin AGEs accumulation and alterations in mitochondrial metabolism. PBMCs from healthy controls exposed to AGEs showed the same mitochondrial alterations observed in patients. These findings support the UPFs role in pediatric obesity, and the need for dietary strategies limiting UPFs exposure for obesity prevention and treatment.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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