Repeated Low-Level Red Light Therapy for the Control of Myopia in Children: A Meta-Analysis of Randomized Controlled Trials
Wang F, Peng W, Jiang Z
Eye & contact lens · 13 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2023-08-08 · Eye Contact Lens · vol. 49 · issue 10 · pp. 438–446
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 15 citations · more than 69% of similar papers · 0.8× the field average
- References
- 51 works
- Access
- Paywalled
- Research areas
- Ophthalmology and Visual Impairment Studies · Corneal surgery and disorders · Retinopathy of Prematurity Studies
- Keywords
- Medicine, Meta-analysis, Randomized controlled trial, Confidence interval, Cochrane Library, Subgroup analysis, Orthokeratology, Ophthalmology, Random effects model, Internal medicine, Pediatrics
- MeSH
- humans, myopia, disease progression, atropine, mydriatics, refraction, ocular, phototherapy, child, randomized controlled trials as topic, axial length, eye
3 authors
From CN
- Fei WangHefei Institutes of Physical Science
- Peng WeiAnhui Medical University; Hefei Institutes of Physical Science; Second Affiliated Hospital of Anhui Medical University
- Zhengxuan Jiang · correspondingAnhui Medical University; Hefei Institutes of Physical Science; Second Affiliated Hospital of Anhui Medical University
Abstract
Background
Repeated low-level red light (RLRL) therapy has been suggested to be effective in children with myopia. However, evidence from randomized controlled trials (RCTs) is still limited. We performed a meta-analysis of RCTs to systematically evaluate the efficacy of RLRL on changes of axial length (AL) and cycloplegic spherical equivalent refraction (SER) in children with myopia.
Methods
Relevant RCTs were obtained through a search of electronic databases including PubMed, Embase, Cochrane Library, Wanfang, and China National Knowledge Infrastructure from inception to September 15, 2022. A random-effects model was used to pool the results after incorporating the influence of potential heterogeneity. Subgroup analyses were performed according to the control treatment and follow-up duration.
Results
A total of seven RCTs involving 1,031 children with myopia, aged 6 to 16 years, were included in the meta-analysis. Compared with control treatment without RLRL, treatment with RLRL was associated with a significantly reduced AL (mean difference [MD]: -0.25 mm, 95% confidence interval [CI]: -0.32 to -0.17, P <0.001; I 2 =13%) and a significantly increased cycloplegic SER (MD: 0.60 D, 95% CI: 0.44-0.76, P <0.001; I 2 =20%). Further subgroup analyses showed consistent results in studies comparing children wearing single vision lenses and those receiving active treatment including orthokeratology or low-dose atropine eye drops, as well as studies of treatment duration of 6 and 12 months.
Conclusions
Results of the meta-analysis suggested that RLRL treatment is effective for slowing down the progression of myopia in children aged 6 to 16 years.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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