Association between dietary magnesium intake and peripheral arterial disease: Results from NHANES 1999-2004
Wu Z, Ruan Z, Liang G, Wang X, Wu J, Wang B
PloS one · 22 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2023-08-11 · PLoS One · vol. 18 · issue 8 · p. e0289973
- Publisher
- Public Library of Science
- Cited
- 23 citations · more than 91% of similar papers · 2.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 35 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Peripheral Artery Disease Management
- Keywords
- Quartile, Medicine, Magnesium, National Health and Nutrition Examination Survey, Incidence (geometry), Magnesium deficiency (plants), Physiology, Dietary Reference Intake, Internal medicine, Nutrient, Endocrinology, Environmental health, Confidence interval, Population, Biology, Chemistry
- MeSH
- humans, magnesium, diet, nutrition surveys, risk factors, adult, aged, middle aged, united states, female, male, peripheral arterial disease
6 authors
From CN
- Zhe Wu
- Zhishen Ruan
- Gang Liang
- Xu Wang
- Jianlin Wu · correspondingShandong University of Traditional Chinese Medicine
- Bin Wang · corresponding
Abstract
Background
Magnesium has been found to have a strong association with peripheral arterial disease (PAD), and dietary magnesium intake shows promise as a predictor of the condition. However, the relationship between low dietary magnesium intake and an increased risk of PAD remains uncertain, and further research is needed to clarify this relationship.
Methods
This study analyzed data from 5969 participants in the National Health and Nutrition Examination Survey (NHANES) of the United States from 1999 to 2004. Multifactorial logistic regression models were used to investigate the association between dietary magnesium intake and PAD.
Results
Participants with PAD had lower dietary magnesium intake compared to those without PAD. After adjusting for all covariates, dietary magnesium intake remained negatively associated with PAD (OR: 0.999, 95% CI: 0.998, 1.000). When dietary magnesium intake was divided into quartiles, compared with the fourth quantile, the first quartile is associated with a higher incidence rate of PAD (OR: 1.560, 95%CI: 1.019, 2.386). Subgroup analysis revealed that the link between dietary magnesium intake and PAD remained significant among specific subgroups, including non-white, never or former smokers, and non-hypertensive, non-diabetic individuals (P < 0.05).
Conclusion
Our study provides evidence that dietary magnesium intake is negatively associated with the incidence of PAD. Therefore, people with inadequate dietary magnesium intake, particularly those with excessively low intake, should increase their magnesium intake to reduce the risk of PAD.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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