Interaction between Serum Cotinine and Magnesium Intake with Childhood Asthma: A Cross-Sectional Study
Cao J, Liu M, Wang Z, Huang Y, Zheng K
International archives of allergy and immunology · 3 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2023-01-01 · Int Arch Allergy Immunol · vol. 184 · issue 11 · pp. 1090–1098
- Publisher
- Karger Publishers
- Cited
- 5 citations · more than 64% of similar papers · 0.6× the field average
- References
- 26 works
- Access
- Paywalled
- Research areas
- Magnesium in Health and Disease · Ion Channels and Receptors · Asthma and respiratory diseases
- Keywords
- Cross-sectional study, Cotinine, Medicine, Asthma, Immunology, Magnesium, Environmental health, Internal medicine, Chemistry, Nicotine, Pathology
- MeSH
- humans, asthma, magnesium, cotinine, nutrition surveys, cross-sectional studies, tobacco smoke pollution, male
5 authors
From CN
- Jianwei CaoZhongshan People's Hospital
- Meiling LiuZhongshan People's Hospital
- Zhongquan WangZhongshan People's Hospital
- Ying HuangGuangdong Medical College
- Kaijun ZhengZhongshan People's Hospital
Abstract
Introduction
Serum cotinine and magnesium intake are often associated with childhood asthma. This study evaluated the interaction between serum cotinine and magnesium intake and childhood asthma.
Methods
This cross-sectional study included 14,159 subjects from the National Health and Nutrition Examination Survey 2005-2018. Serum cotinine levels were classified according to the lower quartile: ≤0.2089 ng/mL as low level and >0.2089 ng/mL as high level. Magnesium intake was categorized as high (>98 mg/1,000 kcal) or low level (≤98 mg/1,000 kcal) based on the upper quartile. Weighted logistic regression analyses were adopted to analyze the association between cotinine, magnesium intake, and childhood asthma. Additionally, the combined effect of cotinine and magnesium intake on childhood asthma risk was examined. The stratified analyses were based on gender, body mass index, and family history of asthma to further examine the relationship between cotinine, magnesium intake, and childhood asthma.
Results
The prevalence of asthma was approximately 17.56%. Compared to low-level cotinine, high-level cotinine was associated with asthma (odds ratio [OR] = 1.25, 95% confidence interval (CI): 1.04-1.50). Low-level magnesium intake was related to asthma compared with high-level magnesium intake (OR = 1.21, 95% CI: 1.04-1.40). Using interaction analysis, we also found that the combined effect of cotinine and magnesium intake was associated with childhood asthma risk, and the interaction between high-level cotinine and low-level magnesium intake was associated with the highest risk of childhood asthma (OR = 1.35, 95% CI: 1.04-1.74). Additionally, this interaction was also found in males, overweight/non-overweight, and those with family history of asthma.
Conclusion
There was an interaction between serum cotinine and magnesium intake on childhood asthma. The results suggested that implementing smoking bans in certain settings (e.g., communities, schools) and promoting the consumption of magnesium-rich foods may be effective strategies for preventing childhood asthma.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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