Funded in part by Pfizer
Cholecalciferol Use Is Associated With a Decreased Risk of Incident Morphometric Vertebral Fractures in Acromegaly
Chiloiro S, Frara S, Gagliardi I, Bianchi A, Giampietro A, Medici M, Allora A, di Filippo L, Ambrosio MR, Pontecorvi A, Zatelli MC, De Marinis L, Giustina A
The Journal of clinical endocrinology and metabolism · 18 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Industry funded
- Company
- Pfizer
- Authors
- At least one author declares a financial tie to industry
- Grants
- Pfizer (56843615).)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2023-08-22 · J Clin Endocrinol Metab · vol. 109 · issue 1 · pp. e58–e68
- Publisher
- Oxford University Press
- Cited
- 27 citations · more than 95% of similar papers · 3.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 66 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Pituitary Gland Disorders and Treatments · Vitamin K Research Studies · Vitamin D Research Studies
- Keywords
- Medicine, Interquartile range, Acromegaly, Internal medicine, Retrospective cohort study, Odds ratio, Osteoporosis, Complication, Cholecalciferol, Concomitant, Gastroenterology, Logistic regression, Vitamin D and neurology, Surgery, Hormone, Growth hormone
- MeSH
- humans, acromegaly, spinal fractures, cholecalciferol, retrospective studies, bone density
13 authors
From IT
- Sabrina ChiloiroUniversità Cattolica del Sacro Cuore; Agostino Gemelli University Polyclinic
- Stefano FraraVita-Salute San Raffaele University; IRCCS Ospedale San Raffaele
- Irene GagliardiUniversity of Ferrara
- Antonio BianchiUniversità Cattolica del Sacro Cuore; Agostino Gemelli University Polyclinic
- Antonella GiampietroUniversità Cattolica del Sacro Cuore; Agostino Gemelli University Polyclinic
- Margherita MediciUniversity of Ferrara
Abstract
Context
Skeletal fragility is observed in 30% to 60% of acromegaly patients, representing an emerging complication of the disease that increases disability. Despite several studies having investigated the clinical and hormonal prognostic factors for the occurrence of vertebral fractures (VFs) in acromegaly, very few data are available on their prevention/treatment including the effect of vitamin D (VD) supplementation, which has been reported to have a fracture-protective effect in several studies in patients with osteoporosis.
Objective
We aimed to investigate the role of cholecalciferol (D3) supplementation in the prevention of incident VFs (i-VFs) in acromegaly.
Methods
A longitudinal, retrospective and multicenter study was performed on 61 acromegaly patients treated and untreated with D3 supplementation.
Results
Twenty-six patients were treated with D3 supplementation according to clinical guidelines. The median D3 weekly dosage was 8500 IU (interquartile range [IQR]: 3900). The median duration of D3 supplementation was 94 months (IQR: 38). At last follow-up, i-VFs were diagnosed in 14 patients (23%). I-VFs were less prevalent in patients on D3 supplementation (14.3% of cases) compared to patients not treated with D3 (85.7%; P = .02). The final level of serum V25OH-D was significantly lower in patients who developed i-VFs (28.6 ng/mL, IQR: 4.1) compared to patients who did not develop i-VFs (34.2 ng/mL, IQR: 9.6; P = .05). The logistic regression confirmed the protective role of D3 supplementation on the occurrence of i-VFs (odds ratio: 0.16; 95% CI, 0.03-0.79; P = .01).
Conclusion
It is likely that D3 supplementation could lead to a reduction in i-VFs in acromegaly.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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