The Effects of Creatine Monohydrate Loading on Exercise Recovery in Active Women throughout the Menstrual Cycle
Gordon AN, Moore SR, Patterson ND, Hostetter ME, Cabre HE, Hirsch KR, Hackney AC, Smith-Ryan AE
Nutrients · 15 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NIDDK NIH HHS
- Authors
- At least one author declares a financial tie to industry
- Grants
- National Institute of Diabetes and Digestive and Kidney Diseases (T32‐DK064584)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2023-08-13 · Nutrients · vol. 15 · issue 16 · p. 3567
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 21 citations · more than 91% of similar papers · 2.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 44 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Muscle metabolism and nutrition · Sports Performance and Training · Exercise and Physiological Responses
- Keywords
- Sprint, Creatine, Creatine Monohydrate, Medicine, Follicular phase, Anaerobic exercise, Internal medicine, Luteal phase, Endocrinology, Menstrual cycle, Hormone, Placebo, Physical therapy
- MeSH
- humans, creatine, progesterone, cross-over studies, menstrual cycle, bicycling, dietary supplements, adolescent, adult, female, young adult
8 authors
From US
- Amanda N. GordonUniversity of North Carolina at Chapel Hill
- Sam R. MooreUniversity of North Carolina at Chapel Hill
- Noah D. PattersonUniversity of North Carolina at Chapel Hill
- Maggie E. HostetterUniversity of North Carolina at Chapel Hill
- Hannah E. CabreUniversity of North Carolina at Chapel Hill
- Katie R. HirschUniversity of South Carolina
Abstract
Creatine supplementation improves anaerobic performance and recovery; however, to date, these outcomes have not been well explored in females. This study evaluated the effect of creatine monohydrate loading on exercise recovery, measured by heart rate variability (HRV) and repeated sprint performance, in women across the menstrual cycle. In this randomized, double-blind, cross-over study, 39 women (mean ± standard deviation: age: 24.6 ± 5.9 years, height: 172.5 ± 42.3 cm, weight: 65.1 ± 8.1 kg, BF: 27.4 ± 5.8%) were randomized to a creatine monohydrate (n = 19; 20 g per day in 4 × 5 g doses) or non-caloric PL group (n = 20). HRV was measured at rest and after participants completed a repeated sprint cycling test (10 × 6 s maximal sprints). Measurements were conducted before and after supplementation in the follicular/low hormone and luteal/high hormone phases. Creatine monohydrate supplementation did not influence HRV values, as no significant differences were seen in HRV values at rest or postexercise. For repeated sprint outcomes, there was a significant phase × supplement interaction (p = 0.048) for fatigue index, with the greatest improvement seen in high hormone in the creatine monohydrate group (-5.8 ± 19.0%) compared to changes in the PL group (0.1 ± 8.1%). Sprint performance and recovery were reduced by the high hormone for both groups. Though not statistically significant, the data suggests that creatine monohydrate could help counteract performance decrements caused by the high hormone. This data can help inform creatine monohydrate loading strategies for females, demonstrating potential benefits in the high hormone phase.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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