Altered Oral Nitrate Reduction and Bacterial Profiles in Hypertensive Women Predict Blood Pressure Lowering Following Acute Dietary Nitrate Supplementation
Willmott T, Ormesher L, McBain AJ, Humphreys GJ, Myers JE, Singh G, Lundberg JO, Weitzberg E, Nihlen C, Cottrell EC
Hypertension (Dallas, Tex. : 1979) · 20 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2023-09-13 · Hypertension · vol. 80 · issue 11 · pp. 2397–2406
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 24 citations · more than 92% of similar papers · 2.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 82 works
- Access
- Open access (repository copy) · CC-BY
- Research areas
- Sodium Intake and Health · Nitric Oxide and Endothelin Effects · Gut microbiota and health
- Keywords
- Nitrate, Nitrite, Blood pressure, Saliva, Medicine, Nitrate reductase, Internal medicine, Oral Microbiome, Endocrinology, Oral administration, Physiology, Animal science, Chemistry, Biology
- MeSH
- humans, bacteria, beta vulgaris, hypertension, nitrates, nitrites, rna, ribosomal, 16s, pregnancy, blood pressure, dietary supplements, adult, female
10 authors
From GB, SE
- Thomas Willmott
- Laura Ormesher
- Andrew J. McBain
- Gavin J. Humphreys
- Jenny Myers
- Gurdeep SinghManchester Academic Health Science Centre
Abstract
Background
The efficacy of dietary nitrate supplementation to lower blood pressure (BP) in pregnant women is highly variable. We aimed to investigate whether differences in oral microbiota profiles and oral nitrate-reducing capacity may explain interindividual differences in BP lowering following nitrate supplementation.
Methods
Participants recruited for this study were both pregnant and nonpregnant women, with or without hypertension (n=55). Following an overnight fast, plasma, saliva, and tongue scraping samples were collected for measurement of nitrate/nitrite concentrations, oral NaR (nitrate reductase) activity, and microbiota profiling using 16S rRNA gene sequencing. Baseline BP was measured, followed by the administration of a single dose of dietary nitrate (400 mg nitrate in 70 mL beetroot juice). Post-nitrate intervention, plasma and salivary nitrate/nitrite concentrations and BP were determined 2.5 hours later.
Results
Women with hypertension had significantly lower salivary nitrite concentrations (P=0.006) and reduced abundance of the nitrate-reducing taxa Veillonella(P=0.007) compared with normotensive women. Oral NaR activity was not significantly different in pregnant versus nonpregnant women (P=0.991) but tended to be lower in hypertensive compared with normotensive women (P=0.099). Oral NaR activity was associated with both baseline diastolic BP (P=0.050) and change in diastolic BP following acute nitrate intake (P=0.01, adjusted for baseline BP).
Conclusions
The abundance and activity of oral nitrate-reducing bacteria impact both baseline BP as well as the ability of dietary nitrate supplementation to lower BP. Strategies to increase oral nitrate-reducing capacity could lower BP and enhance the efficacy of dietary nitrate supplementation, in pregnancy as well as in nonpregnant adults.
Registration
URL: https://www.
Clinicaltrials
gov; Unique identifier: NCT03930693.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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