Funded in part by Pfizer, GlaxoSmithKline, Novartis Pharmaceuticals Corporation
Association between Elevated Magnesium Intake and Reduced Risk of Recurrent Falls and Frailty in Osteoarthritis: Data from the Osteoarthritis Initiative
Zheng Z, Luo H, Xu W, Shi L, Wang F, Qiu Y, Wang L, Xu Y, Sun C, Xue Q
The journal of nutrition, health & aging · 4 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Industry funded
- Government
- U.S. Department of Health and Human Services
- Company
- Pfizer
- Company
- GlaxoSmithKline
- Company
- Novartis Pharmaceuticals Corporation
- Government
- National Institutes of Health
- Grants
- U.S. Department of Health and Human Services (N01-AR-2-2258); U.S. Department of Health and Human Services (N01-AR-2-2261); U.S. Department of Health and Human Services (N01-AR-2-2262); National Institutes of Health (N01 AR‐2‐2260); Novartis Pharmaceuticals Corporation (N01-AR-2-2261); National Institutes of Health (N01-AR-2-2258); Novartis Pharmaceuticals Corporation (N01-AR-2-2260); U.S. Department of Health and Human Services (N01-AR-2-2259); National Institutes of Health (N01‐AR‐2‐2259); U.S. Department of Health and Human Services (N01-AR-2-2260); National Institutes of Health (N01-AR-2-2261); Pfizer (N01-AR-2-2262); GlaxoSmithKline (N01-AR-2-2262); National Institutes of Health (N01-AR-2-2262)
Based on 5 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2023-09-01 · J Nutr Health Aging · vol. 27 · issue 9 · pp. 775–784
- Publisher
- Springer Science+Business Media
- Cited
- 6 citations · more than 67% of similar papers · 0.7× the field average
- References
- 47 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Bone health and osteoporosis research
- Keywords
- Medicine, Confounding, Osteoarthritis, Odds ratio, Prospective cohort study, Body mass index, Cohort study, Internal medicine, Lower risk, Food intake, Physical therapy, Confidence interval
- MeSH
- humans, osteoarthritis, knee, magnesium, risk factors, follow-up studies, prospective studies, dietary fiber, aged, male, frailty
10 authors
From CN
- Zitian ZhengChinese Academy of Medical Sciences & Peking Union Medical College; Peking University
- Hao Lun LuoChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Wanghong XuSun Yat-sen University; Sun Yat-sen Memorial Hospital
- L. ShiChinese Academy of Medical Sciences & Peking Union Medical College
- Fang WangChinese Academy of Medical Sciences & Peking Union Medical College
- Yan QiuChinese Academy of Medical Sciences & Peking Union Medical College
Abstract
Objectives
The objective of this 8-year follow-up study was to investigate the relationship between magnesium intake and frailty, as well as recurrent falls, in individuals diagnosed with Osteoarthritis (OA) or those at a heightened risk for developing the condition.
Methods
This study utilized data from the Osteoarthritis Initiative (OAI) database and conducted a prospective cohort study with a 8-year follow-up period. Total magnesium intake from both food sources and supplements was assessed using a food frequency questionnaire (FFQ), while frailty and recurrent falls were evaluated through established criteria and self-report, respectively. To account for potential confounding factors, various covariates were considered, and statistical analyses, including generalized additive mixed models (GAMMs), were employed to examine the associations.
Results
Among the 4,667 participants with OA, those with lower total magnesium intake were characterized by younger age, a higher proportion of African American individuals, higher body mass index (BMI), and lower dietary fiber intake (P<0.001). Notably, this group exhibited higher odds of experiencing recurrent falls and frailty (P = 0.034 and 0.006, respectively). Controlling for various factors, the GAMMs consistently revealed negative correlations between magnesium intake and the likelihood of frailty and recurrent falls, with each 1 mg/1000 kcal increase in magnesium intake associated with a 0.5% reduced frailty risk (p < 0.001) and a 0.2% decreased risk of recurrent falls (p = 0.001). Subgroup analyses suggested that increased total magnesium intake from both food sources and supplements may exert a more pronounced preventive effect on recurrent falls and frailty in men, older adults, individuals with normal BMI, and those with higher dietary fiber intake.
Conclusions
Elevated total magnesium intake from both food sources and supplements was found to be associated with a decreased risk of recurrent falls and frailty in individuals diagnosed with OA or those at risk of developing the condition. These findings imply that increased total magnesium intake might be beneficial in managing the risk of these outcomes, particularly within specific subgroups, including men, older adults, those with a normal BMI, and those with higher dietary fiber intake.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.