Association of Red Meat Intake and Colorectal Cancer among East-Asians: A Systematic Review and Meta-analysis of Observational Studies Performed between 2011-2021
Cheung HS, Lu LY, So WL, Wong HW, Wong SH, Mak CM
Journal of gastrointestinal and liver diseases : JGLD · 5 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2023-09-28 · J Gastrointestin Liver Dis · vol. 32 · issue 3 · pp. 377–383
- Publisher
- Editura Medicală Universitară Iuliu Hatieganu
- Cited
- 7 citations · more than 49% of similar papers · 0.4× the field average
- References
- 38 works
- Access
- Open access (free to publish) · CC-BY-NC-ND
- Research areas
- Nutritional Studies and Diet · Meat and Animal Product Quality · Colorectal Cancer Screening and Detection
- Keywords
- Medicine, Funnel plot, Colorectal cancer, Publication bias, Red meat, Meta-analysis, Odds ratio, Incidence (geometry), Confidence interval, Internal medicine, Cohort study, Prospective cohort study, Cancer, Relative risk, Pathology
- MeSH
- humans, colorectal neoplasms, incidence, risk assessment, risk factors, observational studies as topic, red meat, asia, eastern, east asian people
6 authors
From CN, HK
- Hoi Shan CheungDuchess of Kent Children's Hospital; Hong Kong Children's Hospital
- Lok Yee LuDuchess of Kent Children's Hospital; Hong Kong Children's Hospital
- Kevin Wang Leong SoDuchess of Kent Children's Hospital; Hong Kong Children's Hospital
- Ho Wai WongDuchess of Kent Children's Hospital; Hong Kong Children's Hospital
- Sei Hei WongDuchess of Kent Children's Hospital; Hong Kong Children's Hospital
- Chloe Miu MakDuchess of Kent Children's Hospital; Hong Kong Children's Hospital
Abstract
Background and aims
Colorectal cancer has the third highest incidence and second highest mortality among all cancers worldwide. Although numerous studies investigating the associations between high red meat intake and risk of colorectal cancer have been published, the association between the intake of red meat and the risk of colorectal cancer in Asians remains unclear. We performed a systematic review and meta-analysis of cohort and case-control studies to estimate the association between red meat intake and colorectal cancer incidence rate between 2011-2021.
Method
We searched PubMed database from 1 Jan 2011 to 21 July 2021. Prospective cohort studies and nested case-control studies that reported results on the association between red meat consumption and colorectal cancer were included in the meta-analysis. The outcome of interest was the association between the intake of red meat and the risk of colorectal cancer. We performed a meta-analysis to calculate the odds ratios (OR) with 95% confidence intervals (CI).
Results
A total of 5 studies enrolling 48,158 participants were included. The results showed no significant association between red meat intake and colorectal cancer risks (OR=1.38; 95%CI: 0.98-1.93). The aspect of the corresponding funnel plot suggested the presence of significant publication bias. Egger's test confirmed the significant asymmetry of the funnel plot (t = 9.3024, p = 0.0026).
Conclusions
Contrary to many other meta-analyses, our study showed that intake of red meat was not associated with increased risk of colorectal cancer in East-Asians from China, Japan and South Korea. However, due to the limited number of included papers and the lack of confounders adjustments, our results warrant cautious interpretations.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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