Nonlinear relationship between dietary calcium and magnesium intake and peripheral neuropathy in the general population of the United States
Wu Z, Yang X, Ruan Z, Li L, Wu J, Wang B
Frontiers in nutrition · 5 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2023-09-18 · Front Nutr · vol. 10 · p. 1217465
- Publisher
- Frontiers Media
- Cited
- 5 citations · more than 64% of similar papers · 0.6× the field average
- References
- 33 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Pain Mechanisms and Treatments · Trace Elements in Health
- Keywords
- Medicine, Peripheral neuropathy, Calcium, Magnesium, Internal medicine, Quantile, Peripheral, Endocrinology, Incidence (geometry), Quantile regression, National Health and Nutrition Examination Survey, Population, Diabetes mellitus, Chemistry, Environmental health
6 authors
From CN
- Zhe WuShandong University of Traditional Chinese Medicine; Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
- Xuesong YangAffiliated Hospital of Shandong University of Traditional Chinese Medicine
- Zhishen RuanShandong University of Traditional Chinese Medicine; Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
- Lianlian LiShandong University of Traditional Chinese Medicine; Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
- Jianlin Wu · correspondingShandong University of Traditional Chinese Medicine
- Bin Wang · correspondingShandong University of Traditional Chinese Medicine; Affiliated Hospital of Liaoning University of Traditional Chinese Medicine; Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Abstract
Background
Calcium and magnesium are essential minerals that have significant roles in nerve function and regulation. There may be a correlation between dietary calcium and magnesium intake and peripheral neuropathy. However, this relationship remains unclear and requires further study.
Methods
Data from 7,726 participants in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2004 were analyzed in this study. The relationship between total dietary calcium and magnesium intake, as well as each quantile, and peripheral neuropathy was analyzed using a multifactor logistic regression model. To illustrate the dose-response relationship between calcium and magnesium intake and peripheral neuropathy, we utilized a restricted cubic spline (RCS) plot.
Results
Our analysis found a positive correlation between dietary intake of calcium and magnesium and peripheral neuropathy (calcium: OR 1.000, 95% CI 1.000-1.000; magnesium: OR 1.001, 95% CI 1.00-1.002). Participants in the first and third quantiles of dietary calcium intake had a significantly higher incidence of peripheral neuropathy than those in the second quantile (OR 1.333, 95% CI 1.034-1.719, OR 1.497, 95% CI 1.155-1.941). Those in the first and third quantiles of dietary magnesium intake also had a significantly higher incidence of peripheral neuropathy than those in the second quantile (OR 1.275, 95% CI 1.064-1.528, OR 1.525, 95% CI 1.231-1.890). The restricted cubic spline analysis revealed a U-shaped nonlinear relationship between dietary intake of calcium and magnesium and peripheral neuropathy.
Conclusion
The study found a U-shaped non-linear relationship between dietary calcium and magnesium intake levels and peripheral neuropathy, indicating that both excessive and insufficient intake of calcium and magnesium can increase the incidence of peripheral neuropathy.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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