Exploring the differences in serum metabolite profiles after intake of red meat in women with rheumatoid arthritis and a matched control group
Lindqvist HM, Gjertsson I, Hulander E, Bärebring L, Winkvist A
European journal of nutrition · 8 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
- Intake measured by
- Food provided by researchers
Who paid for it
- Funding
- Independent funding
- Government
- Vetenskapsrådet
- University or hospital
- Göteborgs Universitet
- Nonprofit
- Magnus Bergvalls Stiftelse
- Government
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Government
- swedish government under the ALF agreement
- University or hospital
- University of Gothenburg
- Grants
- Vetenskapsrådet (2016-01216); Vetenskapsrådet (2021-00954); Magnus Bergvalls Stiftelse (2020-03869); Magnus Bergvalls Stiftelse (2019-03320)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2023-10-09 · Eur J Nutr · vol. 63 · issue 1 · pp. 221–230
- Publisher
- Springer Science+Business Media
- Cited
- 10 citations · more than 86% of similar papers · 1.8× the field average
- References
- 39 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Rheumatoid Arthritis Research and Therapies · Metabolomics and Mass Spectrometry Studies · Nutritional Studies and Diet
- Keywords
- Postprandial, Rheumatoid arthritis, Metabolite, Medicine, Internal medicine, Meal, Red meat, Phenylalanine, Insulin, Biology, Biochemistry
- MeSH
- humans, arthritis, rheumatoid, phenylalanine, case-control studies, research design, female, metabolomics, red meat
5 authors
From SE
- Helen M. Lindqvist · correspondingUniversity of Gothenburg
- Inger GjertssonSahlgrenska University Hospital; University of Gothenburg
- Erik HulanderUniversity of Gothenburg
- Linnea BärebringUniversity of Gothenburg
- Anna WinkvistUniversity of Gothenburg
Abstract
Purpose
Studies have suggested that women with RA tend to avoid red meat more often than women without RA, based on their perception that it exacerbates their symptoms. Therefore, the aim of this study is to investigate and compare the postprandial metabolic response following the consumption of a red meat meal in patients with RA and a matched control group.
Methods
Participants were challenged with a meal with red meat and blood samples were collected before and at 0.5, 1, 2, 3 and 5 h after the meal. Serum metabolites were quantified by Nuclear Magnetic Resonance (NMR) analysis. Orthogonal Projections to Latent Structures with Discriminant Analysis (OPLS-DA) was used to evaluate separation by metabolites due to diagnosis of RA or not and to identify changes in metabolites related to RA. Incremental area under the curve was calculated for univariate comparisons for 23 metabolites.
Results
The matched groups, including 22 women with RA and 22 women without RA, did not differ significantly in age, body mass index, diet quality or reported physical activity. OPLS-DA models had a limited quality indicating that there were no differences in metabolite patterns between the groups. However, phenylalanine was significantly higher in concentration in women with RA compared to controls in both fasting and postprandial samples.
Conclusion
To conclude, this well-controlled postprandial intervention study found a significantly higher concentration of phenylalanine in both fasting and postprandial samples of women with RA compared to matched women without RA. These findings warrant further investigation in larger studies.
Trial registration
The PIRA (Postprandial Inflammation in Rheumatoid Arthritis) trial is Registered at Clinicaltrials.gov (NCT04247009).
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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