Hypohydration induced by prolonged cycling in the heat increases biomarkers of renal injury in males
Juett LA, Drury JE, Greensmith TB, Thompson AP, Funnell MP, James LJ, Mears SA
European journal of applied physiology · 3 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Authors
- At least one author declares a financial tie to industry
Based on full-text disclosure statement.
Publication
- Published
- 2023-10-17 · Eur J Appl Physiol · vol. 124 · issue 4 · pp. 1085–1096
- Publisher
- Springer Science+Business Media
- Cited
- 5 citations · more than 68% of similar papers · 0.7× the field average
- References
- 42 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Thermoregulation and physiological responses · Exercise and Physiological Responses · Muscle metabolism and nutrition
- Keywords
- Urine specific gravity, Cycling, Medicine, Urine osmolality, Urine, Urinary system, Internal medicine, Plasma osmolality, Osmole, Chemistry, Endocrinology, Urology
- MeSH
- kidney, humans, dehydration, water, adult, male, hot temperature, young adult, biomarkers
7 authors
From GB
- Loris A. JuettLoughborough University; Loughborough College
- Jack E. DruryLoughborough University
- Thomas B. GreensmithLoughborough University
- Alfie P. ThompsonLoughborough University
- Mark P. FunnellLoughborough University
- Lewis John JamesLoughborough University
Abstract
Purpose
Recent studies have shown that hypohydration can increase renal injury. However, the contribution of hypohydration to the extent of renal injury is often confounded by exercise induced muscle damage. Therefore, the aim of the present study was to investigate the effect of manipulating hydration status during moderate-intensity cycling in the heat on biomarkers of renal injury.
Methods
Following familiarisation, fourteen active males (age: 21 [20-22] y; BMI: 22.1 ± 1.9 kg/m2; V ˙ O2peak: 55 ± 9 mL/kg/min) completed two experimental trials, in a randomised cross-over design. Experimental trials consisted of up to 120 min of intermittent cycling (~ 50% Wpeak) in the heat (~ 35 °C, ~ 50% relative humidity). During exercise, subjects consumed either a water volume equal to 100% body mass losses (EU) or minimal water (HYP; 75-100 mL) to induce ~ 3% body mass loss. Blood and urine samples were collected at baseline, 30 min post-exercise and 24 h post-baseline, with an additional urine sample collected immediately post-exercise.
Results
Thirty minutes post-exercise, body mass and plasma volume were lower in HYP than EU (P < 0.001), whereas serum and urine osmolality (P < 0.001), osmolality-corrected urinary kidney injury molecule-1 concentrations (HYP: 2.74 [1.87-5.44] ng/mOsm, EU: 1.15 [0.84-2.37] ng/mOsm; P = 0.024), and percentage change in osmolality-corrected urinary neutrophil gelatinase-associated lipocalin concentrations (HYP: 61 [17-141] %, EU: 7.1 [- 4 to 24] %; P = 0.033) were greater in HYP than EU.
Conclusion
Hypohydration produced by cycling in the heat increased renal tubular injury, compared to maintaining euhydration with water ingestion.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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