High Intake of Dietary Cholesterol Decreases the Risk of All-Cause Dementia and AD Dementia: A Results from Framingham Offspring Cohort
Wang M, Wang Y, Zhang Y, Zhang W, Wang Y, Fan R, Wen Y
The journal of prevention of Alzheimer's disease · 5 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2023-05-25 · J Prev Alzheimers Dis · vol. 10 · issue 4 · pp. 748–755
- Publisher
- Springer Science+Business Media
- Cited
- 4 citations · more than 74% of similar papers · 0.9× the field average
- References
- 32 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Nutritional Studies and Diet · Dementia and Cognitive Impairment Research · Alzheimer's disease research and treatments
- Keywords
- Dementia, Medicine, Framingham Heart Study, Offspring, Interquartile range, Cohort study, Cohort, Internal medicine, Diabetes mellitus, Cholesterol, Stroke (engine), Prospective cohort study, Framingham Risk Score, Gerontology, Endocrinology, Disease, Pregnancy, Biology
- MeSH
- humans, dementia, alzheimer disease, cholesterol, dietary, risk factors, prospective studies, middle aged
7 authors
From CN
- Mingmin WangFirst People's Hospital of Chongqing
- Yanqiu Wang
- Yuzhu Zhang
- Weipeng Zhang
- Youjie Wang
- Ruitai Fan
Abstract
Background
Dietary cholesterol has been confirmed to be associated with high risks of diabetes, hypertension, and stroke, but whether it is detrimental to cognitive health is highly debated. This study aimed to investigate the associations between dietary cholesterol and all-cause dementia and AD dementia.
Methods
This prospective study analyzed Framingham Offspring Study cohort (FOS) participants who were dementia-free at baseline and had detailed information on daily diet (measured by food frequency questionnaires) and demographic characteristics. Surveillance for incident dementia commenced at examination 5 (1991-1995) through 2018 and continued for approximately 30 years.
Results
A total of 3249 subjects were included with a mean age of 54.7 years (SD: 9.8). During a median follow-up of 20.2 years (interquartile range: 14.2-24.8), a total of 312 incident dementia events occurred, including 211 (67.7%) cases of AD dementia. After multivariate adjustments for established dementia risk factors, participants with the highest intake of dietary cholesterol had a lower risk of all-cause dementia (HR: 0.70; 95% CI: 0.57-0.93) and AD dementia (HR: 0.68; 95% CI: 0.60-0.88) relative to individuals with the lowest intake. However, the associations were not significant for the group with a medium intake of dietary cholesterol.
Conclusion
High intake of dietary cholesterol was associated with a decreased risk of all-cause dementia and AD dementia. The findings of this observational study need to be confirmed by other studies to highlight the role of dietary cholesterol in the development of neurodegenerative diseases.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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