Funded in part by Bio-Tech Pharmacal
Diet's Role in Modifying Risk of Alzheimer's Disease: History and Present Understanding
Grant WB, Blake SM
Journal of Alzheimer's disease : JAD · 56 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People, plus animal or lab work
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Industry funded
- Company
- Bio-Tech Pharmacal
- Authors
- At least one author declares a financial tie to industry
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2023-11-07 · J Alzheimers Dis · vol. 96 · issue 4 · pp. 1353–1382
- Publisher
- IOS Press
- Cited
- 73 citations · more than 100% of similar papers · 16.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 260 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Nutritional Studies and Diet · Diet and metabolism studies · Consumer Attitudes and Food Labeling
- Keywords
- Mediterranean diet, Medicine, Dash, Environmental health, Observational study, Glycemic load, Disease, Risk factor, Insulin resistance, Obesity, DASH diet, Metabolic syndrome, Red meat, Glycemic index, Diabetes mellitus, Glycemic, Endocrinology, Internal medicine, Pathology
- MeSH
- humans, alzheimer disease, diet, risk factors, prospective studies, cross-sectional studies
2 authors
From US
- William Burgess Grant · correspondingSunlight Nutrition and Health Research Center
- Steven M. Blake
Abstract
Diet is an important nonpharmacological risk-modifying factor for Alzheimer's disease (AD). The approaches used here to assess diet's role in the risk of AD include multi-country ecological studies, prospective and cross-sectional observational studies, and laboratory studies. Ecological studies have identified fat, meat, and obesity from high-energy diets as important risk factors for AD and reported that AD rates peak about 15-20 years after national dietary changes. Observational studies have compared the Western dietary pattern with those of the Dietary Approaches to Stop Hypertension (DASH), Mediterranean (MedDi), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets. Those studies identified AD risk factors including higher consumption of saturated and total fats, meat, and ultraprocessed foods and a lower risk of AD with higher consumption of fruits, legumes, nuts, omega-3 fatty acids, vegetables, and whole grains. Diet-induced factors associated with a significant risk of AD include inflammation, insulin resistance, oxidative stress, elevated homocysteine, dietary advanced glycation end products, and trimethylamine N-oxide. The molecular mechanisms by which dietary bioactive components and specific foods affect risk of AD are discussed. Given most countries' entrenched food supply systems, the upward trends of AD rates would be hard to reverse. However, for people willing and able, a low-animal product diet with plenty of anti-inflammatory, low-glycemic load foods may be helpful.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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