The effects of blueberry and cranberry supplementation on blood pressure in patients with cardiovascular diseases: A systematic review and meta-analysis of randomized clinical trials
Delpino FM, Dos Santos FS, Flores TR, Cerqueira HS, Santos HO, Santos HO
Phytotherapy research : PTR · 8 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Government
- National Council for Scientific and Technological Development (CNPq)
Based on 2 listed funder(s).
Publication
- Published
- 2023-11-14 · Phytother Res · vol. 38 · issue 2 · pp. 646–661
- Publisher
- Wiley
- Cited
- 7 citations · more than 55% of similar papers · 0.5× the field average
- References
- 82 works
- Access
- Free to read
- Research areas
- Blood Pressure and Hypertension Studies · Pharmacology and Obesity Treatment · Consumer Attitudes and Food Labeling
- Keywords
- Meta-analysis, Medicine, Randomized controlled trial, Blood pressure, Confidence interval, CRANBERRY JUICE, Internal medicine, Clinical trial, Traditional medicine
- MeSH
- humans, vaccinium macrocarpon, fruit, cardiovascular diseases, blood pressure, dietary supplements, randomized controlled trials as topic, blueberry plants
5 authors
From BR
- Felipe Mendes Delpino · correspondingUniversidade Federal de Pelotas
- Francine Silva dos SantosUniversidade de São Paulo
- Thaynã Ramos FloresUniversidade Federal de Pelotas
- Henrique Santa Capita CerqueiraUniversidade de São Paulo
- Heitor Oliveira SantosUniversidade Iguaçu
Abstract
Blueberries and cranberries are berry fruits with the highest number of randomized clinical trials (RCTs) focusing on blood pressure (BP). This systematic review and meta-analysis of RCTs analyzed the effects of blueberry and cranberry supplementation alone and in concert with systolic BP (SBP) and diastolic BP (DBP) in patients with cardiometabolic diseases. The searches were performed until August 2023 in the following databases: PubMed, Scopus, Web of Science, Cochrane, and Embase. Studies that examined the effects of blueberry or cranberry intake/supplementation were included. The risk of bias was evaluated using the Rob 2 scale. A meta-analysis was performed to estimate the effects of blueberry and cranberry supplementation on BP levels in patients with cardiometabolic diseases. A total of 17 articles were included, from which two found significant results from blueberry and/or cranberry supplementation in reducing BP. Pooled results revealed statistically non-significant reductions of -0.81 mm Hg for SBP (95% confidence interval [CI]: -2.26, 0.63; I2 = 0%) and -0.15 mm Hg for DBP (95% CI: -1.36, 1.05; I2 = 27%). Blueberry and/or cranberry supplementation had neutral effects on SBP and DBP in patients with cardiometabolic diseases, regardless of duration or age. Further high-quality studies are needed to firmly establish clinical efficacy.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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