Effects of six-month creatine supplementation on patient- and clinician-reported outcomes, and tissue creatine levels in patients with post-COVID-19 fatigue syndrome
Slankamenac J, Ranisavljev M, Todorovic N, Ostojic J, Stajer V, Ostojic SM
Food science & nutrition · 17 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Authors
- At least one author declares a financial tie to industry
Based on full-text disclosure statement.
Publication
- Published
- 2023-09-20 · Food Sci Nutr · vol. 11 · issue 11 · pp. 6899–6906
- Publisher
- Wiley
- Cited
- 21 citations · more than 91% of similar papers · 2.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 23 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Muscle metabolism and nutrition · Fibromyalgia and Chronic Fatigue Syndrome Research · Exercise and Physiological Responses
- Keywords
- Creatine, Coronavirus disease 2019 (COVID-19), Medicine, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 2019-20 coronavirus outbreak, Internal medicine, Physical therapy, Virology, Disease
6 authors
From RS, NO, HU
- Jelena SlankamenacUniversity of Novi Sad
- Marijana RanisavljevUniversity of Novi Sad
- Nikola TodorovićUniversity of Novi Sad
- Jelena Nesovic OstojicUniversity of Novi Sad
- Valdemar ŠtajerUniversity of Novi Sad
- Sergej M. Ostojić · correspondingUniversity of Novi Sad; University of Agder; University of Pecs
Abstract
Dietary creatine has been recently put forward as a possible intervention strategy to reduce post-COVID-19 fatigue syndrome yet no clinical study so far evaluated its efficacy and safety for this perplexing condition. In this parallel-group, randomized placebo-controlled double-blind trial, we analyzed the effects of 6-month creatine supplementation (4 g of creatine monohydrate per day) on various patient- and clinician-reported outcomes, and tissue creatine levels in 12 patients with post-COVID-19 fatigue syndrome. Creatine intake induced a significant increase in tissue creatine levels in vastus medialis muscle and right parietal white matter compared to the baseline values at both 3-month and 6-month follow-ups (p p p = .04), and significantly improved scores for several post-COVID-19 fatigue syndrome-related symptoms (e.g., ageusia, breathing difficulties, body aches, headache, and difficulties concentrating) at 6-month follow-up (p < .05). Taking creatine for 6 months appears to improve tissue bioenergetics and attenuate clinical features of post-COVID-19 fatigue syndrome; additional studies are warranted to confirm our findings in various post-COVID-19 cohorts.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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