Association of Whole Grain Consumption and Cognitive Decline: An Investigation From a Community-Based Biracial Cohort of Older Adults
Liu X, Beck T, Dhana K, Desai P, Krueger KR, Tangney CC, Holland TM, Agarwal P, Evans DA, Rajan KB
Neurology · 12 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- Government
- National Institute on Aging
- Government
- NIA NIH HHS
- Grants
- National Institute on Aging (R01 AG058679); National Institute on Aging (R01AG073627)
Based on 3 listed funder(s).
Publication
- Published
- 2023-11-21 · Neurology · vol. 101 · issue 22 · pp. e2277–e2287
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 17 citations · more than 94% of similar papers · 3.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 55 works
- Access
- Open access (repository copy)
- Research areas
- Nutritional Studies and Diet · Obesity, Physical Activity, Diet · Consumer Attitudes and Food Labeling
- Keywords
- Cognition, Episodic memory, Cognitive decline, Demography, Ethnic group, Whole grains, Medicine, Association (psychology), Effects of sleep deprivation on cognitive performance, Gerontology, Psychology, Internal medicine, Psychiatry, Food science
- MeSH
- humans, diet, cognition, aging, aged, female, male, whole grains, cognitive dysfunction
10 authors
From US
- Xiaoran LiuRush University Medical Center
- Todd L. BeckRush University Medical Center
- Klodian DhanaRush University Medical Center
- Pankaja M DesaiRush University Medical Center
- Kristin R. KruegerRush University Medical Center
- Christy TangneyRush University Medical Center
Abstract
Background and objectives
To examine the association of whole grain consumption and longitudinal change in global cognition, perceptual speed, and episodic memory by different race/ethnicity.
Methods
We included 3,326 participants from the Chicago Health and Aging Project who responded to a Food Frequency Questionnaire (FFQ), with 2 or more cognitive assessments. Global cognition was assessed using a composite score of episodic memory, perceptual speed, and the Mini Mental State Examination (MMSE). Diet was assessed by a 144-item FFQ. Linear mixed-effects models were used to estimate the association of intakes of whole grains and cognitive decline.
Results
This study involved 3,326 participants (60.1% African American [AA], 63.7% female) with a mean age of 75 years at baseline and a mean follow-up of 6.1 years. Higher consumption of whole grains was associated with a slower rate of global cognitive decline. Among AA participants, those in the highest quintile of whole grain consumption had a slower rate of decline in global cognition (β = 0.024, 95% CI [0.008-0.039], p = 0.004), perceptual speed (β = 0.023, 95% CI [0.007-0.040], p = 0.005), and episodic memory (β = 0.028, 95% CI [0.005-0.050], p = 0.01) compared with those on the lowest quintile. Regarding the amount consumed, in AA participants, those who consumed >3 servings/d vs those who consumed p = 0.0093). In White participants, with >3 servings/d, we found a suggestive association of whole grains with global cognitive decline when compared with those who consumed p = 0.08).
Discussion
Among AA participants, individuals with higher consumption of whole grains and more frequent consumption of whole grain had slower decline in global cognition, perceptual speed, and episodic memory. We did not see a similar trend in White adults.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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