Circadian alignment of food intake and glycaemic control by time-restricted eating: A systematic review and meta-analysis
Rovira-Llopis S, Luna-Marco C, Perea-Galera L, Bañuls C, Morillas C, Victor VM
Reviews in endocrine & metabolic disorders · 37 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- European Commission
- Government
- Generalitat Valenciana
- University or hospital
- Universitat de València
- Government
- Ministerio de Ciencia e Innovación
- Government
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
- Government
- Instituto de Salud Carlos III
- Government
- European Regional Development Fund
- Government
- FP7 Science in Society
- University or hospital
- Universitat de Valencia
- Grants
- Instituto de Salud Carlos III (CP19/00077); Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (UGP‐21‐236); Generalitat Valenciana (CIGE/2022/122); Ministerio de Ciencia e Innovación (PI22/00424); European Regional Development Fund (CB06/04/0071); European Regional Development Fund (CIBERehd CB06/04/0071); Universitat de València (ZA21-049); Ministerio de Ciencia e Innovación (CB06/04/0071); Instituto de Salud Carlos III (CB06/04/0071); Ministerio de Ciencia e Innovación (CIBEREHD CB06/04/0071); Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (UGP-15-220); Instituto de Salud Carlos III (PI22/00424); Instituto de Salud Carlos III (PI21/01160); Instituto de Salud Carlos III (CIBERehd CB06/04/0071)
Based on 9 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2023-11-22 · Rev Endocr Metab Disord · vol. 25 · issue 2 · pp. 325–337
- Publisher
- Springer Science+Business Media
- Cited
- 46 citations · more than 90% of similar papers · 2.3× the field average
- References
- 61 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Dietary Effects on Health · Circadian rhythm and melatonin · Diet and metabolism studies
- Keywords
- Glycemic, Meta-analysis, Medicine, Circadian rhythm, Cochrane Library, Internal medicine, Subgroup analysis, Intermittent fasting, Endocrinology, Systematic review, Insulin, Gastroenterology, MEDLINE, Biology, Biochemistry
- MeSH
- humans, blood glucose, fasting, circadian rhythm, eating, glycemic control
6 authors
From ES
- Susana Rovira‐Llopis · correspondingUniversitat de València; Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana; INCLIVA Health Research Institute
- Clara Luna-MarcoFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana; Hospital Universitario Doctor Peset
- Laura Perea‐GaleraFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana; Hospital Universitario Doctor Peset
- Celia BañulsFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana; Hospital Universitario Doctor Peset
- Carlos MorillasFundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana; Hospital Universitario Doctor Peset
- Víctor M. Víctor · correspondingUniversitat de València; Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana; Hospital Universitario Doctor Peset
Abstract
Daily rhythms of metabolic function are supported by molecular circadian clock systems that are strongly regulated by feeding and fasting. Intermittent fasting diets have been associated with weight loss and improved metabolism. However, the effects of time-restricted eating (TRE) on glycemic parameters are still under debate. In this review, we aim to systematically analyze the effects of TRE on glycemic parameters. We searched on PubMed, EMBASE, and the Cochrane Library for controlled studies in which subjects followed TRE for at least 4 weeks. 20 studies were included in the qualitative systematic review, and 18 studies (n = 1169 subjects) were included in the meta-analysis. Overall, TRE had no significant effect on fasting glucose (Hedges's g = -0.08; 95% CI:-0.31,0.16; p = 0.52), but it did reduce HbA1c levels (Hedges's g = -0.27; 95% CI: -0.47, -0.06; p = 0.01). TRE significantly reduced fasting insulin (Hedges's g = -0.40; 95% CI: -0.73,-0.08; p = 0.01) and showed a tendency to decrease HOMA-IR (Hedges's g = -0.32; 95% CI:-0.66,0.02; p = 0.06). Interestingly, a cumulative analysis showed that the beneficial effects of TRE regarding glucose levels were less apparent as studies with later TRE windows (lTRE) were being included. Indeed, a subgroup analysis of the early TRE (eTRE) studies revealed that fasting glucose was significantly reduced by eTRE (Hedges's g = -0.38; 95% CI:-0.62, -0.14; p < 0.01). Our meta-analysis suggests that TRE can reduce HbA1c and insulin levels, and that timing of food intake is a crucial factor in the metabolic benefit of TRE, as only eTRE is capable of reducing fasting glucose levels in subjects with overweight or obesity.PROSPERO registration number CRD42023405946.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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