Dietary nitrate, nitrite, and nitrosamine in association with diabetes: a systematic review and meta-analysis
Nguyen NN, Tran LTD, Ho NDK, Huynh LBP, Nguyen HS, Chen YC
Nutrition reviews · 9 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Science and Technology Council
- Government
- National Science and Technology Council of Taiwan
- Grants
- National Science and Technology Council (MOST 110-2628-B-038-014); National Science and Technology Council (MOST 111–2628-B-038–022); National Science and Technology Council (NSTC 112-2628-B-038-005)
Based on 2 listed funder(s).
Publication
- Published
- 2023-11-25 · Nutr Rev · vol. 82 · issue 11 · pp. 1473–1481
- Publisher
- Oxford University Press
- Cited
- 14 citations · more than 62% of similar papers · 0.7× the field average
- References
- 21 works
- Access
- Paywalled
- Research areas
- Nitric Oxide and Endothelin Effects · Water Treatment and Disinfection · Soil Carbon and Nitrogen Dynamics
- Keywords
- Odds ratio, Medicine, Context (archaeology), Confidence interval, Type 2 diabetes, Diabetes mellitus, Internal medicine, Meta-analysis, Endocrinology, Biology
- MeSH
- humans, diabetes mellitus, diabetes mellitus, type 2, nitrates, nitrites, nitrosamines, diet, risk factors
6 authors
From TW, VN
- Nam Nhat NguyenTaipei Medical University
- Linh T D TranTaipei Medical University
- Ngan D K HoTaipei Medical University
- Linh Ba Phuong HuynhTaipei Medical University
- Hung Song NguyenPham Ngoc Thach University of Medicine; Children's Hospital 1
- Yang‐Ching Chen · correspondingTaipei Medical University Hospital; Taipei Medical University
Abstract
Context
Diabetes is a global health concern, and diet is a contributing factor to diabetes. Findings regarding the connection between nitrate, nitrite, and nitrosamine and diabetes risk are inconsistent.
Objective
The aim was to examine the effects of these dietary compounds on diabetes risk.
Data sources
The data were sourced from PubMed, EMBASE, Scopus, and Web of Science until February 28, 2023. Studies that reported individual-level consumption of these compounds were included. Review articles or ecological studies were excluded.
Data extraction
The number of events and total observations were recorded.
Data analysis
The pooled odds ratio (OR) was calculated and displayed in a forest plot. Subgroup and sensitivity analyses were predefined. A dose-response meta-analysis was conducted to determine the exposure intervals that may increase the risk of disease. Six observational reports that met the inclusion criteria were included, involving 108 615 individuals. Participants in the highest quantile of nitrite intake had a greater risk of diabetes compared with those in the lowest quantile (OR, 1.61; 95% confidence interval [CI], 1.08-2.39; I2 = 74%, P = 0.02). Higher nitrosamine consumption tended to increase diabetes risk (OR, 1.52; 95% CI, 0.76-3.04; I2 = 76%; P = 0.24). The relationship was stronger for type 1 (OR, 1.79; 95% CI, 1.20-2.67; I2 = 58%; P < 0.01) than for type 2 diabetes (OR, 1.42; 95% CI, 0.86-2.37; I2 = 71%; P = 0.17). Additionally, nitrite consumption had a dose-dependent association with both phenotypes. No association was found between diabetes risk and high nitrate intake (OR, 1.01; 95% CI, 0.87-1.18; I2 = 28%; P = 0.87).
Conclusion
Attention should be paid to the consumption of nitrite-containing foods.
Systematic review registration
PROSPERO registration no. CRD42023394462 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=394462).
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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