Dietary Magnesium Intake and Kidney Stone: The National Health and Nutrition Examination Survey 2011-2018
Shringi S, Raker CA, Tang J
Rhode Island medical journal (2013) · 7 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2023-12-01 · R I Med J (2013) · vol. 106 · issue 11 · pp. 20–25
- Publisher
- National Institutes of Health
- Cited
- 6 citations · more than 77% of similar papers · 1.0× the field average
- References
- 0 works
- Access
- Paywalled
- Research areas
- Kidney Stones and Urolithiasis Treatments · Magnesium in Health and Disease · Parathyroid Disorders and Treatments
- Keywords
- National Health and Nutrition Examination Survey, Medicine, Quartile, Odds ratio, Logistic regression, Kidney disease, Internal medicine, Diabetes mellitus, Univariate analysis, Environmental health, Endocrinology, Confidence interval, Multivariate analysis, Population
- MeSH
- humans, kidney calculi, magnesium, diet, nutrition surveys, regression analysis
3 authors
From US
- Sandipan ShringiBrown University
- Christina RakerBrown University
- Jie TangBrown University
Abstract
Background
The association between dietary magnesium intake (DMI) and kidney stone (KS) disease is not clear.
Aim
To determine the association between DMI and prevalent KS disease defined as self-report of any previous episode of KS.
Methods
We examined The National Health and Nutrition Examination Survey (NHANES) 2011-2018 and used logistic regression analyses adjusting for demographics, BMI, histories of hypertension, diabetes, thiazide use, cigarette smoking, alcohol drinking, relevant dietary and supplemental intakes to determine the independent association between DMI and prevalent KS disease.
Results
A total of 19,271 participants were eligible for the final analysis, including 1878 prevalent KS formers. Mean DMI among stone formers was 295.4 mg/day, as compared to 309.6 mg/day among non-stone formers (p=0.02). Higher DMI was strongly associated with lower odds of prevalent KS disease in univariate analysis regardless of when DMI was analyzed as a continuous variable (OR=0.94, 95% CI: 0.89-0.99, p=0.02) or when the extreme quartiles of DMI were compared (OR=0.74, 95% CI: 0.60-0.92, p=0.007). In the multivariable-adjusted regression analysis, those in the highest quartile of DMI compared to the lowest quartile (≥379 mg vs. <205 mg) had significantly reduced odds of prevalent KS (OR=0.70, 95% CI: 0.52-0.93, p=0.01). When DMI was analyzed as a continuous variable, there was a trend toward reduced odds of prevalent KS disease with higher DMI (OR=0.92 per 100 mg, 95% CI: 0.84-1.01, p=0.07).
Conclusions
Our study suggests that higher DMI is associated with a reduced risk of KS disease. Future prospective studies are needed to clarify the causal relationship between DMI and KS disease.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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