High intake of cruciferous vegetables reduces the risk of gastrointestinal cancers: results from observational studies
Ren HG, Luu HN, Liu Y, Wang DW, Wang DW, Guo X
Critical reviews in food science and nutrition · 12 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- US National Cancer Institute and National Natural Science Foundation
Based on 1 listed funder(s).
Publication
- Published
- 2023-12-05 · Crit Rev Food Sci Nutr · vol. 64 · issue 23 · pp. 8493–8499
- Publisher
- Taylor & Francis
- Cited
- 17 citations · more than 82% of similar papers · 1.4× the field average
- References
- 38 works
- Access
- Paywalled
- Research areas
- Genomics, phytochemicals, and oxidative stress · Helicobacter pylori-related gastroenterology studies
- Keywords
- Medicine, Cruciferous vegetables, Cancer, Internal medicine, Confidence interval, Relative risk, Colorectal cancer, Gastroenterology, Gallbladder cancer
- MeSH
- humans, brassicaceae, vegetables, gastrointestinal neoplasms, diet, risk factors, observational studies as topic
5 authors
From US, CN
- Ren Hong-gangVanderbilt University
- Hung Nguyen LuuUniversity of Pittsburgh; UPMC Hillman Cancer Center
- Ying LiuVanderbilt University
- Dao Wen Wang · correspondingTongji Hospital
- Xingyi Guo · correspondingVanderbilt University
Abstract
The relationship between cruciferous vegetables (CV) and the risk of gastrointestinal (GI) cancers has been extensively investigated. However, epidemiologic investigations have produced inconsistent results. This meta-analysis investigated the association between CV intake and the risk of GI cancers. Due to the heterogeneity, fixed- or random-effects models were used for the analyses. The final analysis included 81 articles covering 89 studies. In comparison to the lowest consumption categories, the highest consumption categories of CV were associated with a lower risk for all GI cancers [rate ratio (RR): 0.81, 95% confidence interval (95% CI) 0.76-0.87]. Compared to a CV intake of 75 g/day, subjects with CV intake <75 g/day experienced a 7% reduction in risk (RR: 0.93; 95% CI: 0.84-0.96) for each 50 g increase in consumption. A negative correlation was identified between CV intake and the risk of esophageal cancer, gastric cancer, liver cancer, pancreatic cancer, and colorectal cancer (CRC), but not gallbladder cancer (RR: 0.70; 95% CI: 0.38-1.27). High intake of broccoli and cabbage was associated with a decreased risk of gastric cancer (RR: 0.64; 95% CI: 0.47-0.87) and gallbladder cancer (RR: 0.46; 95% CI: 0.29-0.75). These results confirm the association between high intake of CV with a reduced risk of GI cancers.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.