Funded in part by Sanofi, Regeneron Pharmaceuticals, Aimmune Therapeutics, Allergy Therapeutics
Partial Egg Consumption Modifies the Diagnostic Performance of Allergy Tests to Predict Outcome of Double-Blind Placebo-Controlled Food Challenges to Egg
Marques-Mejias A, Radulovic S, Foong RX, Bartha I, Krawiec M, Kwok M, Jama Z, Harrison F, Ricci C, Lack G, Du Toit G, Santos AF
The journal of allergy and clinical immunology. In practice · 8 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Industry funded
- Company
- Sanofi
- Company
- Regeneron Pharmaceuticals
- Nonprofit
- Immune Tolerance Network
- Company
- Aimmune Therapeutics
- Company
- Allergy Therapeutics
- Nonprofit
- Action Medical Research
- Government
- National Institute for Health and Care Research
- Nonprofit
- Asthma and Lung UK
- University or hospital
- King's College London
- Nonprofit
- Rosetrees Trust
- Government
- National Institutes of Health
- Government
- Directorate for Biological Sciences
- Government
- Medical Research Council
- Government
- Biotechnology and Biological Sciences Research Council
- Government
- National Institute of Allergy and Infectious Diseases
- Grants
- Medical Research Council (MR/T032081/1); Asthma and Lung UK (AUK‐BC‐2015‐01); Medical Research Council (MR/M008517/1); Biotechnology and Biological Sciences Research Council (M008517); Medical Research Council (MR/M008517/1); Medical Research Council (MC_PC_18052); Medical Research Council (MR/T032081/1); Medical Research Council (MC_PC_18052)
Based on 15 listed funder(s).
Publication
- Published
- 2023-12-27 · J Allergy Clin Immunol Pract · vol. 12 · issue 3 · pp. 660–669.e5
- Publisher
- Elsevier BV
- Cited
- 8 citations · more than 78% of similar papers · 1.1× the field average
- References
- 21 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Food Allergy and Anaphylaxis Research · Asthma and respiratory diseases · Consumer Attitudes and Food Labeling
- Keywords
- Medicine, Egg allergy, Placebo, Double blind, Allergy, Food allergy, Consumption (sociology), Immunology, Pathology, Alternative medicine
- MeSH
- humans, egg hypersensitivity, immunoglobulin e, immunoglobulin g, ovomucin, allergens, skin tests, eggs, egg white, child
12 authors
From GB, ZA
- Andreina Marques‐MejiasSt Thomas' Hospital; Evelina London Children's Healthcare
- Suzana RadulovićSt Thomas' Hospital; Evelina London Children's Healthcare
- Ru‐Xin FoongSt Thomas' Hospital; Evelina London Children's Healthcare
- Irene BarthaSt Thomas' Hospital; Evelina London Children's Healthcare
- Marta KrawiecSt Thomas' Hospital; Evelina London Children's Healthcare
- Matthew KwokKing's College London; King's College School
Abstract
Background
Many children are consuming some egg when they are diagnosed with egg allergy. We hypothesized that egg consumption could modify the diagnostic performance of allergy tests.
Objective
To stratify diagnostic performance of tests according to egg consumption status.
Methods
The BAT2 study (NCT03309488) participants underwent oral food challenge (OFC), food-frequency questionnaires, skin prick test (SPT), specific immunoglobulin E (sIgE) and specific immunoglobulin G4 (sIgG4) and basophil activation test (BAT).
Results
At study entry, 45% of participants reported partial egg consumption ("consumers") and 55% were avoiding egg strictly ("avoiders"). Avoiders had larger SPT (P < .001), higher BAT to egg (P < .001), sIgE to egg white (EW; P = .001) and to ovalbumin (OVA; P = .001), but not to ovomucoid (P = .231). Consumers had higher levels of sIgG4 to all egg allergens (P < .001) than avoiders. In consumers, the test with the best diagnostic performance was BAT (area under the curve [AUC] = .912) followed by SPT to raw egg (AUC = 0.805), EW-sIgE (AUC = 0.738), and OVA-sIgE (AUC = 0.732). In avoiders, the best tests were BAT (AUC = 0.834) and EW-sIgE (AUC = 0.833) followed by OVA-sIgE (AUC = 0.793) and SPT to EW (AUC=0.789). Using 100% sensitivity and 100% specificity cut-offs, the proportion of patients requiring OFC were 33% for BAT, 53% for SPT to raw egg, 61% for OVA-sIgE, and 73% for EW-sIgE for consumers; and 73% for BAT, 79% for EW-sIgE, and 93% for SPT to EW for avoiders.
Conclusions
The diagnostic performance of tests is influenced by the immunomodulatory effect of egg consumption. BAT is the most reliable test and reduced the need for OFC, particularly in partial egg consumers.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.