Relationship of calcium and magnesium intakes with the dietary approaches to stop hypertension score and blood pressure: the International Study of Macro/micronutrients and Blood Pressure
Gibson R, Aljuraiban GS, Oude Griep LM, Vu TH, Steffen LM, Appel LJ, Rodriguez BL, Daviglus ML, Elliott P, Van Horn L, Chan Q
Journal of hypertension · 7 citations
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Institute for Health and Care Research
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Institute of Environmental Health Sciences
- Government
- NHLBI NIH HHS
- Government
- National Institute for Health Research (NIHR)
- Government
- NIEHS NIH HHS
- Grants
- National Heart, Lung, and Blood Institute (R01HL084228); National Heart, Lung, and Blood Institute (R01 HL050490); National Heart, Lung, and Blood Institute (R01 HL065461); National Institute of Environmental Health Sciences (#P30 ES027792); National Institute for Health and Care Research ((NIHR203312); National Heart, Lung, and Blood Institute (R01HL135486)
Based on 6 listed funder(s).
Publication
- Published
- 2023-12-20 · J Hypertens · vol. 42 · issue 5 · pp. 789–800
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 10 citations · more than 77% of similar papers · 1.2× the field average
- References
- 48 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Sodium Intake and Health · Magnesium in Health and Disease · Nutritional Studies and Diet
- Keywords
- Dash, Medicine, DASH diet, Blood pressure, Micronutrient, Internal medicine, Calcium, Endocrinology, Physiology
- MeSH
- humans, hypertension, calcium, dietary, calcium, magnesium, micronutrients, diet, cross-sectional studies, blood pressure, adult, middle aged, united states, female, male, dietary approaches to stop hypertension
11 authors
From GB, SA, US
- Rachel A. GibsonKing's College London; Imperial College London
- Ghadeer S. AljuraibanKing Saud University
- Linda M. Oude GriepUniversity of Cambridge; MRC Epidemiology Unit; Imperial College London
- Thanh‐Huyen T. VuNorthwestern University
- Lyn M. SteffenUniversity of Minnesota
- Lawrence J. AppelJohns Hopkins University
Abstract
Objective
Research investigating calcium and magnesium intakes from the Dietary Approaches to Stop Hypertension (DASH) pattern and other sources in association with blood pressure is limited. We aimed to characterize sources/intake levels of calcium and magnesium in relation to overall diet quality (DASH-score) and determine modification effects with DASH score and blood pressure.
Methods
Cross-sectional United States data (average dietary and supplement intake from four 24 h recalls and eight blood pressure measurements) from two separate visits, 2195 men and women (40-59 years) in the International Study of Macro/Micronutrients and Blood Pressure were analysed. Food-based adherence to the DASH diet was estimated. Linear models tested associations between each 1-point DASH score with blood pressure. Participants were stratified by adherence to sex-specific recommended allowance for magnesium and calcium intakes. Effect-modification was tested across DASH-score quintiles and median of urinary sodium.
Results
DASH-score was inversely associated with SBP in fully adjusted models (-0.27; 95%CI: -0.38 to -0.15 mmHg). SBP was inversely associated with dietary calcium intake from DASH food groups: -1.54 (95% CI: -2.65 to -0.43) mmHg; calcium intake from other non-DASH food groups: -1.62 (95% CI: -2.94 to -0.29) mmHg. Dietary magnesium intake from DASH food groups (-1.59; 95% CI: -2.79, -0.40 mmHg) and from other non-DASH foods (-1.92; 95% CI: -3.31, -0.53 mmHg) was inversely associated with SBP.
Conclusion
A higher DASH score showed a consistent association with lower BP suggesting a relationship between intakes of calcium and Mg with BP regardless of whether the source is part of the DASH diet or not, even when adjusted for supplement intakes.The INTERMAP is registered as NCT00005271 at www.clinicaltrials.gov .
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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