The Effects of Repeated Low-Level Red-Light Therapy on the Structure and Vasculature of the Choroid and Retina in Children with Premyopia
Liu Z, Sun Z, Du B, Gou H, Wang B, Lin Z, Ren N, Pazo EE, Liu L, Wei R
Ophthalmology and therapy · 43 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Grants
- National Natural Science Foundation of China (82070929.)
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-01-10 · Ophthalmol Ther · vol. 13 · issue 3 · pp. 739–759
- Publisher
- Adis, Springer Healthcare
- Cited
- 46 citations · more than 99% of similar papers · 12.1× the field average
- Impact
- Top 10% most cited in its field
- References
- 45 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Ophthalmology and Visual Impairment Studies · Retinopathy of Prematurity Studies · Retinal Diseases and Treatments
- Keywords
- Medicine, Foveal, Ophthalmology, Choroid, Retinal, Retina, Optical coherence tomography, Perfusion, Fluorescein angiography, Nuclear medicine, Cardiology, Optics
10 authors
From CN
- Zhuzhu LiuTianjin Medical University Eye Hospital; Tianjin Medical University
- Ziwen SunTianjin Medical University Eye Hospital; Tianjin Medical University
- Bei DuTianjin Medical University Eye Hospital; Tianjin Medical University
- Huaixue GouTianjin Medical University Eye Hospital; Tianjin Medical University
- Biying WangTianjin Medical University Eye Hospital; Tianjin Medical University
- Zeya LinTianjin Medical University Eye Hospital; Tianjin Medical University
Abstract
Introduction
The purpose of this study was to explore the effects of repeated low-level red-light (RLRL) therapy on the structure and vasculature of the choroid and retina in Chinese children with premyopia.
Methods
This study was a single-center randomized clinical trial. A total of 94 children with premyopia (- 0.50 D < spherical equivalent [SE] ≤ + 0.75 D) were randomly assigned to either the RLRL therapy or control group. Follow-up visits were planned at 1, 3, 6, 9, and 12 months. Optical coherence biometry was used to measure axial length (AL) and anterior segment parameters. Choroidal thickness (CT), retinal thickness (RT), superficial retinal vascular density (SRVD), deep retinal vascular density (DRVD), choriocapillaris perfusion area (CCPA), and choroidal vessel volume (CVV) were measured by optical coherence tomography angiography, centered on the foveal, parafoveal (ParaF), and perifoveal (PeriF) regions.
Results
The thickening of the choroid was observed across the entire macular region at different time points in the RLRL therapy group. Relative to the baseline measurement, foveal CT significantly increased at the 1-month follow-up with RLRL therapy, with a mean (± standard deviation [SD]) adjusted change of 16.96 ± 19.87 μm. The greatest magnitude of foveal CT changes was observed at the 3-month visit (an increase of 19.58 ± 20.59 μm), with a slight reduction in the extent of foveal CT increase at the 6-month visit (an increase of 15.85 ± 23.77 μm). The second greatest CT increase was observed at the 9-month visit (an increase of 19.57 ± 35.51 μm), after which the extent of CT increase gradually decreased until the end of the study at the 12-month visit (an increase of 11.99 ± 32.66 μm). We also observed a significant increase in CT in the ParaF and PeriF areas in the RLRL group over 12 months. In contrast, CT across the entire macular region in the control group significantly decreased throughout the follow-up visits (all P 2), 3-month (an increase of 0.25 mm2), and 12-month visits (an increase of 0.42 mm2) (all P 0.05). Notably, RLRL therapy achieved a notable reduction in SE shift by 73.8%, a substantial decrease in AL change by 67.9%, and a significant reduction in myopia incidence by 45.1% within 1 year.
Conclusion
Our study demonstrated a significant increase in CT and flow in the RLRL-treated eyes throughout the 12-months of the study. Combined with its reduction in spherical equivalent progression and axial elongation, RLRL could be used as an effective therapy for preventing progression in premyopes.
Trial registration
ChiCTR2200062028.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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