Effect of walnut consumption on markers of endothelial function in adults: A systematic review and meta-analysis of randomized controlled trials
Hsu CY, Hsu CY, Alzahrani AA, Maabreh HG, Prasad KDV, Bokov DO, Kareem AH, Alawadi A, Ihsan A, Shakir MN, Alasheqi MQ
Phytotherapy research : PTR · 5 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2024-01-10 · Phytother Res · vol. 38 · issue 3 · pp. 1358–1366
- Publisher
- Wiley
- Cited
- 7 citations · more than 61% of similar papers · 0.7× the field average
- References
- 45 works
- Access
- Free to read
- Research areas
- Nuts composition and effects
- Keywords
- Meta-analysis, Medicine, Randomized controlled trial, Strictly standardized mean difference, Internal medicine, Web of science, MEDLINE, Gastroenterology, Biology, Biochemistry
- MeSH
- humans, juglans, nuts, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, adult, randomized controlled trials as topic
10 authors
From TW, SA, RU, IN, IQ, IR
- Chou‐Yi HsuChia Nan University of Pharmacy and Science
- Abdullah Ali Alzahrani · correspondingTaif University
- Hatem Ghaleb MaabrehPeoples' Friendship University of Russia
- KDV PrasadSymbiosis International University
- Dmitry Olegovich BokovSechenov University; Federal Research Centre of Nutrition and Biotechnology; All-Russian Scientific Research Institute of Food Biotechnology
- Anaheed Hussein KareemAl-Ayen Iraqi University
Abstract
Findings on the effect of walnut consumption on endothelial function are conflicting. Therefore, the present systematic review and meta-analysis summarized available trials in this regard. A systematic search was performed in online databases including PubMed-Medline, Scopus, and ISI Web of Science up to October 2023. Articles that reported the effect of walnut intake on flow-mediated dilation (FMD), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and stimulus-adjusted response measure (SARM) were included. Random effects models for a weighted mean difference (WMD) or standardized mean difference (SMD) were used to test for the overall effect. Six eligible trials were analyzed (250 participants). Walnut intake significantly increased FMD (WMD: 0.94%, 95% CI: 0.12 to 1.75; p = 0.02). However, meta-analysis could not show any beneficial effect of walnut intake on ICAM-1 (SMD: -0.23, 95% CI: -0.68 to 0.22; p = 0.31), VCAM-1 (SMD: -0.02, 95% CI: -1.38 to 1.34; p = 0.97), and SARM (WMD: 0.01%, 95% CI: -0.01 to 0.04; p = 0.28). In conclusion, the present meta-analysis suggests that walnuts may reduce cardiovascular disease risk by improving FMD. However, further studies should be performed on adults to determine the effect of walnut intake on endothelial function.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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