Ashwagandha Ethanol Extract Attenuates Sarcopenia-Related Muscle Atrophy in Aged Mice
Ko JS, Chang BY, Choi YJ, Choi JS, Kwon HY, Lee JY, Kim SY, Choung SY
Nutrients · 9 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Ministry of SMEs and Startups
- Government
- The Technology development Program
- Authors
- At least one author declares a financial tie to industry
- Grants
- Ministry of SMEs and Startups (S3197415)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-01-03 · Nutrients · vol. 16 · issue 1 · p. 157
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 17 citations · more than 90% of similar papers · 2.6× the field average
- References
- 60 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Muscle Physiology and Disorders · Nutrition and Health in Aging · Body Composition Measurement Techniques
- Keywords
- Sarcopenia, Atrophy, Muscle atrophy, Inflammation, Skeletal muscle, Medicine, Mitochondrial biogenesis, Endocrinology, Internal medicine, Biology, Mitochondrion, Biochemistry
- MeSH
- animals, humans, mice, withania, muscular atrophy, inflammation, body weight, ethanol, plant extracts, middle aged, infant, sarcopenia
8 authors
From KR
- Jin-Sung KoDankook University
- BoYoon ChangWonkwang University
- Youngju ChoiDankook University
- Ji‐Soo Choi
- Hee‐Yeon Kwon
- Jae‐Yeon Lee
Abstract
The investigation focused on the impact of Withania somnifera (ashwagandha) extract (WSE) on age-related mechanisms affecting skeletal muscle sarcopenia-related muscle atrophy in aged mice. Beyond evaluating muscular aspects, the study explored chronic low-grade inflammation, muscle regeneration, and mitochondrial biogenesis. WSE administration, in comparison to the control group, demonstrated no significant differences in body weight, diet, or water intake, affirming its safety profile. Notably, WSE exhibited a propensity to reduce epidermal and abdominal fat while significantly increasing muscle mass at a dosage of 200 mg/kg. The muscle-to-fat ratio, adjusted for body weight, increased across all treatment groups. WSE administration led to a reduction in the pro-inflammatory cytokines TNF-α and IL-1β, mitigating inflammation-associated muscle atrophy. In a 12-month-old mouse model equivalent to a 50-year-old human, WSE effectively preserved muscle strength, stabilized grip strength, and increased muscle tissue weight. Positive effects were observed in running performance and endurance. Mechanistically, WSE balanced muscle protein synthesis/degradation, promoted fiber differentiation, and enhanced mitochondrial biogenesis through the IGF-1/Akt/mTOR pathway. This study provides compelling evidence for the anti-sarcopenic effects of WSE, positioning it as a promising candidate for preventing sarcopenia pending further clinical validation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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