Magnesium supplementation beneficially affects depression in adults with depressive disorder: a systematic review and meta-analysis of randomized clinical trials
Moabedi M, Aliakbari M, Erfanian S, Milajerdi A
Frontiers in psychiatry · 18 citations
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2023-12-22 · Front Psychiatry · vol. 14 · p. 1333261
- Publisher
- Frontiers Media
- Cited
- 30 citations · more than 87% of similar papers · 2.0× the field average
- References
- 27 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Heavy Metal Exposure and Toxicity · Bipolar Disorder and Treatment
- Keywords
- Meta-analysis, Randomized controlled trial, Depression (economics), Placebo, Medicine, Strictly standardized mean difference, Clinical trial, Sample size determination, Internal medicine, Systematic review, Depressive symptoms, Major depressive disorder, MEDLINE, Psychiatry, Physical therapy, Anxiety, Alternative medicine, Pathology
4 authors
From IR
- Mahdi MoabediKashan University of Medical Sciences
- Mohammadreza AliakbariKashan University of Medical Sciences
- Shima ErfanianIsfahan University of Medical Sciences
- Alireza Milajerdi · correspondingKashan University of Medical Sciences
Abstract
Background
The findings from randomized clinical trials (RCTs) examining the effect of magnesium supplementation on depression are inconsistent. We decided to conduct a meta-analysis that summarizes all the evidence on the impact of magnesium supplementation on depression scores in adults with depressive disorder.
Methods
We conducted a systematic search in the online databases using all related keywords up to July 2023. We included all randomized clinical trials examining the effect of magnesium, in contrast to placebo, on depression scores.
Results
Finally, seven clinical trials were included in this systematic review, building up a total sample size of 325 individuals with ages ranging from 20 to 60 years on average. These RCTs resulted in eight effect sizes. Our findings from the meta-analysis showed a significant decline in depression scores due to intervention with magnesium supplements [standardized mean difference (SMD): -0.919, 95% CI: -1.443 to -0.396, p = 0.001].
Conclusion
Our review suggests that magnesium supplementation can have a beneficial effect on depression. Future high-quality RCTs with larger sample sizes must be run to interpret this effect of magnesium on depression in clinical settings.
Systematic review registration
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=447909.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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