Effects of time-restricted eating on intrahepatic fat and metabolic health among patients with nonalcoholic fatty liver disease
Deng Y, Liu X, Sun Y, Zhou L, Li Q, Lei Z, Yang F, Chen L, Zhang C, Tan W, Jin X, Han Z, Xu H, Wang Q, Nie Q, Yi H, Bao W, Rong S
Obesity (Silver Spring, Md.) · 15 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- University or hospital
- Wuhan University
- University or hospital
- Wuhan University of Science and Technology
- Grants
- National Natural Science Foundation of China (82073552); National Natural Science Foundation of China (82373575); National Natural Science Foundation of China (82204038)
Based on 3 listed funder(s).
Publication
- Published
- 2024-01-16 · Obesity (Silver Spring) · vol. 32 · issue 3 · pp. 494–505
- Publisher
- Wiley
- Cited
- 22 citations · more than 96% of similar papers · 5.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 43 works
- Access
- Free to read
- Research areas
- Dietary Effects on Health · Liver Disease Diagnosis and Treatment · Diet, Metabolism, and Disease
- Keywords
- Nonalcoholic fatty liver disease, Medicine, Internal medicine, Fatty liver, Gastroenterology, Liver function, Randomization, Randomized controlled trial, Obesity, Endocrinology, Disease
- MeSH
- liver, humans, magnetic resonance imaging, body composition, adult, non-alcoholic fatty liver disease
18 authors
From CN, HK
- Yan DengWuhan University of Science and Technology
- Xiaoming LiuUnion Hospital; Wuhan Union Hospital; Huazhong University of Science and Technology
- Yuzhe SunBGI Group (China); Beijing Graphene Institute; BGI Research
- Li ZhouWuhan University of Science and Technology
- Qiang LiUnion Hospital; Wuhan Union Hospital; Huazhong University of Science and Technology
- Ziqiao LeiUnion Hospital; Wuhan Union Hospital; Huazhong University of Science and Technology
Abstract
Objective
The study's objective was to explore whether early time-restricted eating (eTRE) and late time-restricted eating (lTRE) have different impacts on intrahepatic fat and metabolic health among patients with nonalcoholic fatty liver disease (NAFLD).
Methods
This is an 8-week, randomized, parallel-arm, open-label trial. Forty eligible patients were randomly assigned to eTRE (eating between 8:00 a.m. and 4:00 p.m.) or lTRE (eating between 12:00 p.m. and 8:00 p.m.). The primary outcome was the change of intrahepatic fat measured by magnetic resonance image-derived proton density fat fraction. Secondary outcomes included changes in weight, body composition, liver function, and cardiometabolic factors.
Results
Forty participants who underwent randomization completed the trial (mean age: 38.25 years). The eTRE group had a -3.24% absolute reduction of intrahepatic fat (95% CI: -4.55% to -1.92%) and there was a -3.51% absolute reduction for the lTRE group (95% CI: -5.10% to -1.92%). Changes in intrahepatic fat were not statistically different between the two groups. Both the eTRE and lTRE groups had similar and significant reductions in weight, visceral fat, subcutaneous fat, liver enzymes, and glucose regulatory indicators.
Conclusions
Among patients with NAFLD, both eTRE and lTRE induced significant reductions in intrahepatic fat and improvements in body composition, liver function, and metabolic health with similar magnitude. These findings suggest that eTRE and lTRE are comparable and feasible strategies for NAFLD management.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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