Effects of repeated low-level red-light therapy on macular retinal thickness and microvascular system in children with myopia
Liu L, Wang Y, Liu F, Yu X, Xie L, Tan S, Liu J, Liu Y, Huang J, Zhang S, Jiang Y
Photodiagnosis and photodynamic therapy · 16 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2024-01-18 · Photodiagnosis Photodyn Ther · vol. 45 · p. 103938
- Publisher
- Elsevier BV
- Cited
- 21 citations · more than 97% of similar papers · 5.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 26 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Ophthalmology and Visual Impairment Studies · Retinal Diseases and Treatments · Retinopathy of Prematurity Studies
- Keywords
- Retinal, Medicine, Ophthalmology, Visual acuity, Optical coherence tomography, Significant difference, Internal medicine
- MeSH
- retinal vessels, retina, humans, myopia, photosensitizing agents, photochemotherapy, prospective studies, child, low-level light therapy
11 authors
From CN
- Linlin LiuGannan Medical University; First Affiliated Hospital of Gannan Medical University
- Yuchuan WangGannan Medical University; The People's Hospital of LinXia; First Affiliated Hospital of Gannan Medical University
- Fang LiuGannan Medical University; First Affiliated Hospital of Gannan Medical University
- Xing-Hui YuGannan Medical University; First Affiliated Hospital of Gannan Medical University
- Lian-Feng XieGannan Medical University; First Affiliated Hospital of Gannan Medical University
- Shuxiang TanGannan Medical University; First Affiliated Hospital of Gannan Medical University
Abstract
Objective
The objective of the study was to use optical coherence tomography angiography (OCTA) to analyze the effects of repeated low-level red-light (LLLT) therapy on macular retinal thickness and the microvascular system in children with myopia to evaluate the safety of this therapy.
Methods
This prospective study included 40 school-age children with myopia (80 eyes), aged 7-14 years, who received therapy using a LLLT instrument. At baseline and therapy for 1 month, 3 months, 6 months, all children underwent comprehensive ophthalmological examinations, including slit-lamp examination, uncorrected visual acuity, best-corrected visual acuity, spherical equivalent degree, axial length, and OCTA. The vessel densities of the superficial retinal capillary plexus, macular inner retinal thickness, and full-layer retinal thickness were measured.
Results
The macular inner retinal thickness increased at 1 month and remained unchanged thereafter, It differed significantly in nine areas at 1, 3, and 6 months compared to the thicknesses before therapy (P 0.05). The macular full-layer retinal thickness increased at 1 month and remained unchanged thereafter; the changes showed significant differences at 1 month and 3 months compared to before therapy, for the inner nasal region (P 0.05). The vessel density of the superficial retinal capillary plexus did not differ significantly among the four groups (P > 0.05).
Conclusions
LLLT therapy was safe. The school-aged children exhibited macular thickening after LLLT therapy, which had no significant effect on macular microcirculation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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