The Association between Red Meat Consumption and Advanced Colorectal Adenomas in a Population Undergoing a Screening-Related Colonoscopy in Alberta, Canada
Farah E, Hutchinson JM, Ruan Y, O'Sullivan DE, Hilsden RJ, Brenner DR
Cancers · 4 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2024-01-24 · Cancers (Basel) · vol. 16 · issue 3 · p. 495
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 6 citations · more than 87% of similar papers · 2.3× the field average
- References
- 39 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Colorectal Cancer Screening and Detection · Consumer Attitudes and Food Labeling
- Keywords
- Red meat, Medicine, Colonoscopy, Odds ratio, Colorectal cancer, Logistic regression, Percentile, Context (archaeology), Odds, Population, Internal medicine, Environmental health, Cancer, Pathology, Biology, Mathematics
6 authors
From CA
- Eliya FarahUniversity of Calgary
- John M. HutchinsonUniversity of Calgary
- Yibing RuanUniversity of Calgary; Cancer Care Alberta
- Dylan Edmund O'SullivanUniversity of Calgary; Cancer Care Alberta
- Robert J. HilsdenAlberta Health Services; University of Calgary
- Darren R. Brenner · correspondingUniversity of Calgary; Cancer Care Alberta
Abstract
The association between red meat consumption and colorectal cancer has been rigorously examined. However, a more comprehensive understanding of how the intake of unprocessed red meat contributes to the development of early precancerous colorectal lesions, such as advanced colorectal adenomas (ACRAs), requires further investigation. We examined the associations between different types of red meat intake and ACRAs in a sample population of 1083 individuals aged ≥ 50 years undergoing an initial screening colonoscopy in Calgary, Alberta, Canada. Associations between grams per day of total, processed, and unprocessed red meat from diet history questionnaires and ACRAs were evaluated with multivariable logistic regression models. We also applied cubic spline models fitted with three knots (10th, 50th, and 90th percentiles) to identify potential nonlinear associations. We did not observe a meaningful association between unprocessed red meat intake and the presence of ACRAs. In contrast, for every 10 g/d increase in total and processed meat intake, we observed an increase in the odds of ACRAs at the screening colonoscopy (adjusted odds ratio (OR) = 1.05, 95% [CI = 1.01-1.09], p = 0.04) and (adjusted OR = 1.11, 95% [CI = 1.02-1.20], p = 0.02), respectively. This study highlights the importance of differentiating between types of red meat consumption in the context of dietary risks associated with ACRAs.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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