The interaction between magnesium intake, the genetic variant INSR rs1799817 and colorectal cancer risk in a Korean population: a case-control study
Nguyen LTD, Gunathilake M, Lee J, Oh JH, Chang HJ, Sohn DK, Shin A, Kim J
International journal of food sciences and nutrition · 5 citations
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Research Foundation of Korea
- Government
- International Cooperation & Education Program
- University or hospital
- International Cooperation & Education Program of the National Cancer Center, Korea
- University or hospital
- National Cancer Centre, Korea
- Grants
- National Research Foundation of Korea (2021R1A2C2008439)
Based on 4 listed funder(s).
Publication
- Published
- 2024-02-22 · Int J Food Sci Nutr · vol. 75 · issue 4 · pp. 396–406
- Publisher
- Taylor & Francis
- Cited
- 4 citations · more than 68% of similar papers · 0.8× the field average
- References
- 46 works
- Access
- Open access (repository copy) · CC-BY
- Research areas
- Magnesium in Health and Disease · Digestive system and related health · Parathyroid Disorders and Treatments
- Keywords
- Odds ratio, Medicine, Colorectal cancer, Internal medicine, Cancer, Magnesium, Confidence interval, Case-control study, Population, Endocrinology, Oncology, Gastroenterology, Environmental health, Chemistry
- MeSH
- humans, colorectal neoplasms, genetic predisposition to disease, magnesium, receptor, insulin, antigens, cd, odds ratio, risk factors, case-control studies, polymorphism, single nucleotide, adult, aged, middle aged, female, male, republic of korea, asian people
8 authors
From KR
- Linh Thi Dieu NguyenNational Cancer Center
- Madhawa Neranjan GunathilakeNational Cancer Center
- Jeonghee LeeNational Cancer Center
- Jae Hwan OhNational Cancer Center; National Cancer Center Hospital
- Hee Jin ChangNational Cancer Center; National Cancer Center Hospital
- Dae Kyung SohnNational Cancer Center; National Cancer Center Hospital
Abstract
Magnesium may have a significant impact on the development of cancer. However, the relationship between magnesium intake and the risk of colorectal cancer (CRC) is unclear. Therefore, we evaluated the association between magnesium intake and the risk of CRC, and we investigated how the insulin receptor (INSR) rs1799817 variant impacts this relationship. Data from 1,420 CRC patients and 2,840 controls from the Korean National Cancer Centre were analysed. A higher intake of magnesium was associated with a reduced risk of CRC in the total population (odds ratio (OR) = 0.65, 95% confidence interval (CI) = 0.52-0.81). We found that G + carriers of INSR rs1799817 with higher magnesium intake had a significantly lower risk of CRC (p for interaction = 0.003). Our findings indicated that high magnesium intake could be associated with a decreased risk of CRC, and this association could be modified by the INSR rs1799817 variant.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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