Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation
Gordji-Nejad A, Matusch A, Kleedörfer S, Jayeshkumar Patel H, Drzezga A, Elmenhorst D, Binkofski F, Bauer A
Scientific reports · 36 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Forschungszentrum Jülich
- University or hospital
- RWTH Aachen University
- University or hospital
- Forschungszentrum Jülich GmbH
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-02-28 · Sci Rep · vol. 14 · issue 1 · p. 4937
- Publisher
- Nature Portfolio
- Cited
- 63 citations · more than 100% of similar papers · 13.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 51 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Muscle metabolism and nutrition · Biochemical effects in animals · Sleep and Wakefulness Research
- Keywords
- Sleep deprivation, Creatine, Effects of sleep deprivation on cognitive performance, Sleep (system call), Cognition, Medicine, Neuroscience, Endocrinology, Internal medicine, Bioinformatics, Psychology, Computer science, Biology, Psychiatry
- MeSH
- central nervous system, humans, sleep deprivation, phosphates, creatine, cognition
8 authors
From DE
- Ali Gordji-Nejad · correspondingForschungszentrum Jülich
- Andreas MatuschForschungszentrum Jülich
- Sophie KleedörferRWTH Aachen University
- Harshal PatelRWTH Aachen University
- Alexander E. DrzezgaForschungszentrum Jülich; University of Cologne; German Center for Neurodegenerative Diseases; University Hospital Cologne
- David ElmenhorstForschungszentrum Jülich; University of Cologne; University Hospital Cologne
Abstract
The inverse effects of creatine supplementation and sleep deprivation on high energy phosphates, neural creatine, and cognitive performances suggest that creatine is a suitable candidate for reducing the negative effects of sleep deprivation. With this, the main obstacle is the limited exogenous uptake by the central nervous system (CNS), making creatine only effective over a long-term diet of weeks. Thus far, only repeated dosing of creatine over weeks has been studied, yielding detectable changes in CNS levels. Based on the hypothesis that a high extracellular creatine availability and increased intracellular energy consumption will temporarily increase the central creatine uptake, subjects were orally administered a high single dose of creatinemonohydrate (0.35 g/kg) while performing cognitive tests during sleep deprivation. Two consecutive 31P-MRS scans, 1H-MRS, and cognitive tests were performed each at evening baseline, 3, 5.5, and 7.5 h after single dose creatine (0.35 g/kg) or placebo during sub-total 21 h sleep deprivation (SD). Our results show that creatine induces changes in PCr/Pi, ATP, tCr/tNAA, prevents a drop in pH level, and improves cognitive performance and processing speed. These outcomes suggest that a high single dose of creatine can partially reverse metabolic alterations and fatigue-related cognitive deterioration.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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