Dietary Magnesium Intake Is Inversely Associated With Ulcerative Colitis: A Case-Control Study
Sadeghi O, Khademi Z, Saneei P, Hassanzadeh-Keshteli A, Daghaghzadeh H, Tavakkoli H, Adibi P, Esmaillzadeh A
Crohn's & colitis 360 · 1 citation
How it was studied
- Design
- Case-control study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- University or hospital
- Tehran University of Medical Sciences and Health Services
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-01-01 · Crohns Colitis 360 · vol. 6 · issue 1 · p. otae009
- Publisher
- Oxford University Press
- Cited
- 4 citations · more than 68% of similar papers · 0.9× the field average
- References
- 46 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Biliary and Gastrointestinal Fistulas · Diverticular Disease and Complications
- Keywords
- Ulcerative colitis, Magnesium, Gastroenterology, Medicine, Internal medicine, Food science, Environmental health, Chemistry, Disease
8 authors
From IR, CA
- Omid SadeghiIsfahan University of Medical Sciences; Tehran University of Medical Sciences
- Zeinab KhademiTehran University of Medical Sciences
- Parvane SaneeiIsfahan University of Medical Sciences
- Ammar Hassanzadeh KeshteliIsfahan University of Medical Sciences; University of Alberta
- Hamed DaghaghzadehIsfahan University of Medical Sciences
- Hamid TavakkoliIsfahan University of Medical Sciences
Abstract
Background
Ulcerative colitis (UC) causes long-lasting inflammation and ulcers in the gut. Limited observational data are available linking dietary magnesium intake and UC. In the present study, we aimed to investigate the association between dietary magnesium intake and UC in adults.
Methods
The current population-based case-control study was performed on 109 UC patients and 218 age (±2 years) and sex-matched controls. The diagnosis of UC was made according to the standard criteria by a gastroenterology specialist. Dietary intakes were assessed using a validated self-administrated 106-item dish-based Food Frequency Questionnaire (FFQ). We also used a pretested questionnaire to collect data on potential confounders.
Results
Individuals in the top tertile of magnesium intake were less likely to have UC compared with those in the bottom tertile. A significant inverse relationship was found between dietary magnesium intake and UC (odds ratio [OR]: 0.32, 95% confidence interval [CI]: 0.18-0.59) in the crude model. This relationship was also observed when we took several potential confounding into account (OR: 0.30, 95% CI: 0.14-0.68).
Conclusions
Adherence to a magnesium-rich diet may have a role in preventing UC. However, further studies are needed to confirm our findings.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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