The effects of replacing ghee with rapeseed oil on liver steatosis and enzymes, lipid profile, insulin resistance and anthropometric measurements in patients with non-alcoholic fatty liver disease: a randomised controlled clinical trial
Maleki Sedgi F, Mohammad Hosseiniazar M, Alizadeh M
The British journal of nutrition · 8 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Urmia University
- University or hospital
- Urmia University of Medical Sciences
Based on 2 listed funder(s).
Publication
- Published
- 2024-03-19 · Br J Nutr · vol. 131 · issue 12 · pp. 1985–1996
- Publisher
- Cambridge University Press
- Cited
- 11 citations · more than 92% of similar papers · 2.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 65 works
- Access
- Free to read
- Research areas
- Liver Disease Diagnosis and Treatment · Diet, Metabolism, and Disease · Diet and metabolism studies
- Keywords
- Insulin resistance, Fatty liver, Medicine, Internal medicine, Steatosis, Lipid profile, Triglyceride, Gastroenterology, Body mass index, Liver disease, Insulin, Endocrinology, Cholesterol, Disease
- MeSH
- liver, humans, insulin resistance, alanine transaminase, blood glucose, lipids, anthropometry, adult, middle aged, female, male, non-alcoholic fatty liver disease, rapeseed oil
3 authors
From IR
- Fatemeh Maleki SedgiUrmia University; Urmia University of Medical Sciences
- Mohammadreza Mohammad HosseiniazarUrmia University; Urmia University of Medical Sciences
- Mohammad Alizadeh · correspondingUrmia University; Urmia University of Medical Sciences
Abstract
Non-alcoholic fatty liver disease (NAFLD), which is a prevalent hepatic condition worldwide, is expected to develop into the leading reason for end-stage fatty liver in the forthcoming decades. Incorporating rapeseed oil into a balanced diet may be beneficial in improving NAFLD. The goal of this trial was to evaluate the impact of substituting ghee with rapeseed oil on primary outcomes such as fatty liver and liver enzymes, as well as on secondary outcomes including glycaemic variables, lipid profile and anthropometric measurements in individuals with NAFLD. Over 12 weeks, 110 patients (seventy men and forty women; BMI (mean) 28·2 (sd 1·6 kg/m2); mean age 42 (sd 9·6) years), who daily consumed ghee, were assigned to the intervention or control group through random allocation. The intervention group was advised to substitute ghee with rapeseed oil in the same amount. The control group continued the consumption of ghee and was instructed to adhere to a healthy diet. Results showed a significant reduction in the steatosis in the intervention group in comparison with the control group (P 2), waist (–5·6 cm) and waist:height ratio (–0·04) was seen in the intervention group. The consumption of rapeseed oil instead of ghee caused improvements in liver steatosis and enzymes, glycaemic variables and anthropometric measurements among individuals with NAFLD.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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