Association between dietary magnesium intake and gallstones: the mediating role of atherogenic index of plasma
Du W, Yan C, Wang Y, Song C, Li Y, Tian Z, Liu Y, Shen W
Lipids in health and disease · 23 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2024-03-20 · Lipids Health Dis · vol. 23 · issue 1 · p. 82
- Publisher
- BioMed Central
- Cited
- 23 citations · more than 96% of similar papers · 4.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 61 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Gallbladder and Bile Duct Disorders · Parathyroid Disorders and Treatments
- Keywords
- Gallstones, National Health and Nutrition Examination Survey, Internal medicine, Odds ratio, Medicine, Clinical chemistry, Lipidology, Clinical nutrition, Logistic regression, Gastroenterology, Dyslipidemia, Mediation, Confidence interval, Endocrinology, Physiology, Disease, Environmental health
- MeSH
- humans, gallstones, magnesium, nutrition surveys, adult, atherosclerosis
8 authors
From CN
- Wenyi DuWuxi People's Hospital; Nanjing Medical University
- Chen YanTengzhou Central People's Hospital; Jining Medical University
- Yinkang WangWuxi People's Hospital; Nanjing Medical University
- Chen SongWuxi People's Hospital; Nanjing Medical University
- Yunfan LiJiangsu University; Affiliated Hospital of Jiangsu University
- Zhiqiang TianWuxi People's Hospital; Nanjing Medical University
Abstract
Background
Dyslipidemia and abnormalities in cholesterol metabolism are commonly observed in individuals with gallstone disease. Previous research has demonstrated that dietary magnesium can influence lipid metabolism. The atherogenic index of plasma (AIP) has emerged as a novel lipid marker. This study aimed to examine the possible correlation between dietary magnesium intake and gallstones and the potential mediating role of AIP in US adults.
Methods
A total of 4,841 adults were included in this study from the National Health and Nutrition Examination Survey (NHANES) conducted from 2017 to 2020. A variety of statistical techniques such as logistic regression, subgroup analysis, smoothed curve fitting, and causal mediation analysis were utilized to analyze the information collected from the participants.
Results
In the fully adjusted model, a statistically noteworthy inverse relationship was observed between dietary magnesium intake and the presence of gallstones, as indicated by an odds ratio (OR) of 0.58 and a 95% confidence interval (CI) of (0.42, 0.81). Causal intermediary analysis revealed that the association between magnesium intake and gallstones was partially mediated by AIP, with a mediation ratio of 3.2%.
Conclusion
According to this study, dietary magnesium intake had a significant linear negative association with the prevalence of gallstones, in which AIP played a mediating role. This discovery offers novel perspectives on the prevention and management of gallstones.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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