Funded in part by Taisho Toyama Pharmaceutical Company, Taisho Pharmaceutical (Japan), Taisho Pharmaceutical Co., Ltd.
The Effect of Prior Creatine Intake for 28 Days on Accelerated Recovery from Exercise-Induced Muscle Damage: A Double-Blind, Randomized, Placebo-Controlled Trial
Yamaguchi S, Inami T, Ishida H, Morito A, Yamada S, Nagata N, Murayama M
Nutrients · 5 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- University or hospital
- Keio University
- Company
- Taisho Toyama Pharmaceutical Company
- Company
- Taisho Pharmaceutical (Japan)
- Company
- Taisho Pharmaceutical Co., Ltd.
- Grants
- Taisho Toyama Pharmaceutical Company (H11PA22111)
Based on 4 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-03-20 · Nutrients · vol. 16 · issue 6 · p. 896
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 12 citations · more than 89% of similar papers · 2.6× the field average
- References
- 50 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Muscle metabolism and nutrition · Exercise and Physiological Responses · Sports Performance and Training
- Keywords
- Muscle damage, Placebo, Randomized controlled trial, Creatine, Double blind, Medicine, Physical therapy, Internal medicine, Physical medicine and rehabilitation, Pathology
- MeSH
- muscle, skeletal, humans, creatine, polyesters, dietary supplements, male, myalgia, post-exercise recovery
7 authors
From JP
- Shota Yamaguchi · correspondingKeio University
- Takayuki InamiKeio University
- H. IshidaKeio University
- Akihisa MoritoTaisho Pharmaceutical (Japan)
- Satoshi YamadaTaisho Pharmaceutical (Japan)
- Naoya NagataKeio University
Abstract
Despite the known beneficial effects of creatine in treating exercise-induced muscle damage (EIMD), its effectiveness remains unclear. This study investigates the recovery effect of creatine monohydrate (CrM) on EIMD. Twenty healthy men (21-36 years) were subjected to stratified, randomized, double-blind assignments. The creatine (CRE) and placebo (PLA) groups ingested creatine and crystalline cellulose, respectively, for 28 days. They subsequently performed dumbbell exercises while emphasizing eccentric contraction of the elbow flexors. The EIMD was evaluated before and after exercise. The range of motion was significantly higher in the CRE group than in the PLA group 24 h (h) post exercise. A similar difference was detected in maximum voluntary contraction at 0, 48, 96, and 168 h post exercise (p = 0.017-0.047). The upper arm circumference was significantly lower in the CRE group than in the PLA group at 48, 72, 96, and 168 h post exercise (p = 0.002-0.030). Similar variation was observed in the shear modulus of the biceps brachii muscle at 96 and 168 h post exercise (p = 0.003-0.021) and in muscle fatigue at 0 and 168 h post exercise (p = 0.012-0.032). These findings demonstrate CrM-mediated accelerated recovery from EIMD, suggesting that CrM is an effective supplement for EIMD recovery.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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