Nitrosyl-heme and Heme Iron Intake from Processed Meats and Risk of Colorectal Cancer in the EPIC-Spain Cohort
Rizzolo-Brime L, Lujan-Barroso L, Farran-Codina A, Bou R, Lasheras C, Amiano P, Aizpurua A, Sánchez MJ, Molina-Montes E, Guevara M, Moreno-Iribas C, Gasque A, Chirlaque-López MD, Colorado-Yohar SM, Huerta JM, Zamora-Ros R, Agudo A, Jakszyn P
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 5 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- Instituto de Salud Carlos III
- Government
- Instituto de Salud Carlos III (ISCIII)
- Grants
- Instituto de Salud Carlos III (FI20/00006); Instituto de Salud Carlos III (PI19/00817)
Based on 2 listed funder(s).
Publication
- Published
- 2024-03-28 · Cancer Epidemiol Biomarkers Prev · vol. 33 · issue 6 · pp. 854–856
- Publisher
- American Association for Cancer Research
- Cited
- 5 citations · more than 85% of similar papers · 1.9× the field average
- References
- 8 works
- Access
- Paywalled
- Research areas
- Nutritional Studies and Diet · Alcohol Consumption and Health Effects · Folate and B Vitamins Research
- Keywords
- Heme, EPIC, Colorectal cancer, Cohort, Medicine, Environmental health, Cancer, Internal medicine, Chemistry, Biochemistry, Art
- MeSH
- humans, colorectal neoplasms, heme, risk factors, prospective studies, adult, aged, middle aged, spain, female, male
18 authors
From ES, CO
- Lucía Rizzolo-BrimeBellvitge University Hospital; Institut d'Investigació Biomédica de Bellvitge; Institut Català d'Oncologia
- Leila Luján‐BarrosoBellvitge University Hospital; Institut d'Investigació Biomédica de Bellvitge; Ajuntament de L’Hospitalet; Institut Català d'Oncologia
- Andreu Farrán-CodinaUniversitat de Barcelona
- Ricard BouInstitute of Agrifood Research and Technology
- Cristina LasherasUniversidad de Oviedo
- Pilar AmianoBasque Government; Instituto de Salud Carlos III; Biogipuzkoa Health Research Institute; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
Abstract
Background
The International Agency for Research on Cancer classified processed meats (PM) as "carcinogenic" and red meat as "probably carcinogenic" for humans. The possible relationship between colorectal cancer risk and the mechanisms involved in the carcinogenesis of PMs have not been established yet. Nitrosyl-heme and heme iron have been proposed as potential-related compounds. The aim of this study was to determine the association between nitrosyl-heme and heme iron intake and colorectal cancer risk among participants from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain study.
Methods
This prospective study included 38,262 men and women from the EPIC-Spain study. Food consumption was assessed using diet history and food composition tables. Heme iron and nitrosyl-heme intake were determined by estimating the intake of PM items and conducting laboratory analyses. HR estimates were obtained by proportional hazard models, stratified by age at recruitment and study center and adjusted for sex, total energy intake, education, smoking, body mass index, waist size, physical activity, lifetime alcohol, fibre, calcium, and familiar colorectal cancer history.
Results
During a mean follow-up of 16.7 years, 577 participants were diagnosed with colorectal cancer. We found no overall association between nitrosyl-heme [HRT3vsT1, 0.98; 95% confidence interval (CI), 0.79-1.21] or heme iron intakes (HRT3vsT1, 0.88; 95% CI, 0.70-1.10) with colorectal cancer risk, nor according to tumor subtypes.
Conclusions
Our study found no evidence supporting a link between nitrosyl-heme or heme iron intake and colorectal cancer risk in Spanish subjects.
Impact
As research on nitrosyl-heme is preliminary, more heterogeneous studies are necessary to provide more convincing evidence on their role in colorectal cancer carcinogenesis.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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