Supplements Are Not a Synonym for Safe: Suspected Liver Injury From Ashwagandha
Vazirani S, Kothari A, Fujimoto J, Gomez M
Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 6 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case report (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2023-09-01 · Fed Pract · vol. 40 · issue 9 · pp. 315–319
- Cited
- 9 citations · more than 84% of similar papers · 1.8× the field average
- References
- 17 works
- Access
- Free to read
- Research areas
- Drug-Induced Hepatotoxicity and Protection · Complementary and Alternative Medicine Studies · Poisoning and overdose treatments
- Keywords
- Medicine, Adverse effect, Liver injury, Mood, Drug, Boosting (machine learning), Internal medicine, Pharmacology, Psychiatry
1 author
From US
- Sondra S. Vazirani · correspondingVA Greater Los Angeles Healthcare System
Abstract
Background
As patients look more to alternative herbal and dietary supplements to boost energy and mood, reports are increasing of unintended adverse effects, particularly to the liver.
Case presentation
We report a case of a 48-year-old man with a history of severe alcohol use disorder who presented to the emergency department with a cholestatic pattern of liver injury in the setting of alcohol and use of a testosterone-boosting supplement containing ashwagandha.
Conclusions
Drug-induced liver damage should be considered in patients with alcohol use disorder who present with a cholestatic pattern of liver injury. Although many natural substances are well tolerated, others can have unanticipated and harmful adverse effects and drug interactions. Future research should identify not only potentially harmful substances, but also which patients may be at greatest risk.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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