Withania somnifera (L.) Dunal, a Potential Source of Phytochemicals for Treating Neurodegenerative Diseases: A Systematic Review
Lerose V, Ponticelli M, Benedetto N, Carlucci V, Lela L, Tzvetkov NT, Milella L
Plants (Basel, Switzerland) · 25 citations
How it was studied
- Design
- Systematic review (classified by our AI screen)
- Studied in
- People, plus animal or lab work
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Unclassified
- >Project SPIA—Valorization of by-products from the agro-food chain
- Government
- Affidamento del servizio ai sensi dell’art. 36, comma 2 lettera a) del D.L.gs
- Unclassified
- Project MEPLASUS: MEdicinal PLAnts in a SUstainable Supply chain. Experience of land-use practices ”-OB.FU. 2.99.99.84.00
- Government
- Project RESO - REsilienza e SOstenibilità delle filiere ortofrutticole e cerealicole per valorizzare i territori" - cod. identif. ARS01_01224 -
- Government
- PO FESR BASILICATA 2014–2020—Axis I—Research, Innovation Action and Technological Development—Action 1B.1.2.1—Avviso Pubblico per il sostegno alla creazione e sviluppo dei Cluster Tecnologici della Regione Basilicata e alla realizzazione di progetti di Ricerca e Sviluppo
- Government
- RESO—REsilienza e SOstenibilità delle filiere ortofrutticole e cerealicole per valorizzare i territori”—cod. identif. ARS01_01224—Codice Unico Progetto (CUP)
- Unclassified
- Project SPIA-Valorization of by-products from the agro-food chain
- Government
- Project NODES - Ecosistema dell'Innovazione "Nord Ovest Digitale e Sostenibile"
Based on 8 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-03-08 · Plants (Basel) · vol. 13 · issue 6 · p. 771
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 53 citations · more than 99% of similar papers · 9.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 149 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Phytochemicals and Medicinal Plants · Medicinal Plants and Neuroprotection
- Keywords
- Withania somnifera, Medicine, Traditional medicine, Disease, Systematic review, Neuroprotection, Pharmacology, MEDLINE, Alternative medicine, Biology, Pathology
7 authors
From IT, BG
- Valentina LeroseUniversity of Basilicata
- Maria Ponticelli · correspondingUniversity of Basilicata
- Nadia BenedettoUniversity of Basilicata
- Vittorio CarlucciUniversity of Basilicata
- Ludovica LelaUniversity of Basilicata
- Nikolay TzvetkovBulgarian Academy of Sciences; Institute of Molecular Biology
Abstract
Withania somnifera (L.) Dunal is a medicinal plant belonging to the traditional Indian medical system, showing various therapeutic effects such as anti-cancer, anti-inflammatory, anti-microbial, anti-diabetic, and hepatoprotective activity. Of great interest is W. somnifera's potential beneficial effect against neurodegenerative diseases, since the authorized medicinal treatments can only delay disease progression and provide symptomatic relief and are not without side effects. A systematic search of PubMed and Scopus databases was performed to identify preclinical and clinical studies focusing on the applications of W. somnifera in preventing neurodegenerative diseases. Only English articles and those containing the keywords (Withania somnifera AND "neurodegenerative diseases", "neuroprotective effects", "Huntington", "Parkinson", "Alzheimer", "Amyotrophic Lateral Sclerosis", "neurological disorders") in the title or abstract were considered. Reviews, editorials, letters, meta-analyses, conference papers, short surveys, and book chapters were not considered. Selected articles were grouped by pathologies and summarized, considering the mechanism of action. The quality assessment and the risk of bias were performed using the Cochrane Handbook for Systematic Reviews of Interventions checklist. This review uses a systematic approach to summarize the results from 60 investigations to highlight the potential role of W. somnifera and its specialized metabolites in treating or preventing neurodegenerative diseases.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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