Associations of Dietary Cholesterol Consumption With Incident Diabetes and Cardiovascular Disease: The Role of Genetic Variability in Cholesterol Absorption and Disease Predisposition
Shi S, Dong Y, Wang S, Du X, Feng N, Xu L, Zhong VW
Diabetes care · 4 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- University or hospital
- Innovative Research Team of High-level Local University in Shanghai
- Government
- National Natural Science Foundation of China
- Government
- National Key Research and Development Program of China
- Government
- Shanghai Key Discipline of Public Health Grants Awards
- Grants
- National Key Research and Development Program of China (2022YFC2705203 and 2023YFC2506700); National Natural Science Foundation of China (82373551)
Based on 4 listed funder(s).
Publication
- Published
- 2024-04-09 · Diabetes Care · vol. 47 · issue 6 · pp. 1092–1098
- Publisher
- American Diabetes Association
- Cited
- 6 citations · more than 88% of similar papers · 2.3× the field average
- References
- 30 works
- Access
- Paywalled
- Research areas
- Nutritional Studies and Diet · Genetic Associations and Epidemiology · Cholesterol and Lipid Metabolism
- Keywords
- Medicine, Diabetes mellitus, Genetic predisposition, Internal medicine, Hazard ratio, Cholesterol, Disease, Coronary artery disease, Type 2 diabetes, Endocrinology, Confidence interval
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, genetic predisposition to disease, cholesterol, dietary, membrane transport proteins, adult, aged, middle aged, female, male, atp binding cassette transporter, subfamily g, member 5, atp binding cassette transporter, subfamily g, member 8
7 authors
From CN
- Shuxiao ShiShanghai Jiao Tong University
- Ying DongShanghai Jiao Tong University
- Sujing WangShanghai Jiao Tong University
- Xihao DuShanghai Jiao Tong University
- Nannan FengShanghai Jiao Tong University
- Lan XuShanghai Jiao Tong University
Abstract
Objective
Whether genetic susceptibility to disease and dietary cholesterol (DC) absorption contribute to inconsistent associations of DC consumption with diabetes and cardiovascular disease (CVD) remains unclear.
Research design and methods
DC consumption was assessed by repeated 24-h dietary recalls in the UK Biobank. A polygenetic risk score (PRS) for DC absorption was constructed using genetic variants in the Niemann-Pick C1-Like 1 and ATP Binding Cassettes G5 and G8 genes. PRSs for diabetes, coronary artery disease, and stroke were also created. The associations of DC consumption with incident diabetes (n = 96,826) and CVD (n = 94,536) in the overall sample and by PRS subgroups were evaluated using adjusted Cox models.
Results
Each additional 300 mg/day of DC consumption was associated with incident diabetes (hazard ratio [HR], 1.17 [95% CI, 1.07-1.27]) and CVD (HR, 1.09 [95% CI, 1.03-1.17]), but further adjusting for BMI nullified these associations (HR for diabetes, 0.99 [95% CI, 0.90-1.09]; HR for CVD, 1.04 [95% CI, 0.98-1.12]). Genetic susceptibility to the diseases did not modify these associations (P for interaction ≥0.06). The DC-CVD association appeared to be stronger in people with greater genetic susceptibility to cholesterol absorption assessed by the non-high-density lipoprotein cholesterol-related PRS (P for interaction = 0.04), but the stratum-level association estimates were not statistically significant.
Conclusions
DC consumption was not associated with incident diabetes and CVD, after adjusting for BMI, in the overall sample and in subgroups stratified by genetic predisposition to cholesterol absorption and the diseases. Nevertheless, whether genetic predisposition to cholesterol absorption modifies the DC-CVD association requires further investigation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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