Association between dietary magnesium intake, inflammation, and neurodegeneration
Alateeq K, Walsh EI, Ambikairajah A, Cherbuin N
European journal of nutrition · 14 citations
How it was studied
- Design
- Cross-sectional study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Australian National University
- University or hospital
- King Saud University
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-04-10 · Eur J Nutr · vol. 63 · issue 5 · pp. 1807–1818
- Publisher
- Springer Science+Business Media
- Cited
- 21 citations · more than 95% of similar papers · 4.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 79 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Heavy Metal Exposure and Toxicity
- Keywords
- Inflammation, Medicine, Internal medicine, Endocrinology, White matter, Neuroprotection, C-reactive protein, Hyperintensity, National Health and Nutrition Examination Survey, Physiology, Magnetic resonance imaging, Population
- MeSH
- brain, humans, neurodegenerative diseases, inflammation, magnesium, c-reactive protein, diet, adult, aged, middle aged, female, male, biomarkers, united kingdom
4 authors
From AU, SA
- Khawlah Alateeq · correspondingAustralian National University; King Saud Medical City; King Saud University
- Erin WalshAustralian National University
- Ananthan AmbikairajahAustralian National University; University of Canberra
- Nicolas CherbuinAustralian National University
Abstract
Background
Consistent evidence shows that magnesium (Mg) intake is associated with lower blood pressure (BP), and that lower BP is associated with improved cerebral health. However, recent findings indicate that the positive effect of dietary Mg intake on cerebral health is not mediated by a decrease in BP. As Mg's anti-inflammatory action is a plausible alternative mechanism, the objective of this study was to investigate the associations between Mg intake and inflammation to determine whether it mediates any neuroprotective effect.
Methods
Participants from the UK Biobank (n = 5775, aged 40-73 years, 54.7% female) were assessed for dietary magnesium using an online food questionnaire, brain and white matter lesion (WML) volumes were segmented with FreeSurfer software, and inflammation markers including high-sensitivity C-reactive protein (hs-CRP), leukocyte, erythrocyte count, and Glycoprotein acetylation (GlycA) were measured using specific laboratory techniques such as immunoturbidimetry, automated cell counting, and nuclear magnetic resonance. Hierarchical linear regression models were performed to investigate the association between dietary Mg, and inflammatory markers and between dietary Mg, brain and WMLs volumes. Mediation analysis was performed to test a possible mediation role of inflammation on the association between dietary Mg and brain and WMLs volumes.
Results
Higher dietary Mg intake was associated with lower inflammation: hs-CRP level (- 0.0497%; 95% confidence interval [CI] - 0.0497%, - 0.0199%) leukocytes count (- 0.0015%; 95%CI - 0.00151%, - 0.0011%), and GlycA (- 0.0519%; 95%CI - 0.1298%, - 0.0129%). Moreover, higher dietary Mg intake was associated with larger grey matter volume (0.010%; 95%CI 0.004%, 0.017%), white matter volume (0.012%; 95%CI 0.003, 0.022) and right hippocampal volume (0.002%; 95%CI 0.0007, -0.0025%). Lower hs-CRP levels mediated the positive association between higher dietary Mg intake and larger grey matter volume.
Conclusions
The anti-inflammatory effects of dietary Mg intake in the general population, appears to mediate its neuroprotective effect.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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