Association of Ultraprocessed Food Consumption with Risk of Cardiovascular Disease Among Individuals with Type 2 Diabetes: Findings from the UK Biobank
Li Y, Lai Y, Geng T, Xia PF, Chen JX, Tu ZZ, Yang K, Liao YF, Liu G, Pan A
Molecular nutrition & food research · 13 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- University or hospital
- Deutsches Krebsforschungszentrum
- Government
- National Natural Science Foundation of China
- Government
- National Key Research and Development Program of China
- Government
- Fundamental Research Funds for the Central Universities
- Government
- Hubei Province Science Fund for Distinguished Young Scholars
- Government
- National Basic Research Program of China
- Grants
- National Key Research and Development Program of China (82073554); Fundamental Research Funds for the Central Universities (82021005); Fundamental Research Funds for the Central Universities (2021GCRC076); National Natural Science Foundation of China (82073554); National Key Research and Development Program of China (2022YFC3600600); National Natural Science Foundation of China (82 021 005); National Key Research and Development Program of China (82021005); Fundamental Research Funds for the Central Universities (81,930,124); National Natural Science Foundation of China (81930124); National Key Research and Development Program of China (82273623); National Natural Science Foundation of China (82,273,623); National Natural Science Foundation of China (2022YFC3600600); National Natural Science Foundation of China (2021CFA048); National Natural Science Foundation of China (82192902); National Key Research and Development Program of China (81930124)
Based on 6 listed funder(s).
Publication
- Published
- 2024-04-19 · Mol Nutr Food Res · vol. 68 · issue 9 · p. e2300314
- Publisher
- Wiley
- Cited
- 11 citations · more than 94% of similar papers · 4.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 44 works
- Access
- Free to read
- Research areas
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Nutrition, Genetics, and Disease
- Keywords
- Medicine, Hazard ratio, Type 2 diabetes, Internal medicine, Body mass index, Disease, Diabetes mellitus, Cystatin C, Lower risk, Confidence interval, Physiology, Endocrinology, Renal function
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, type 2, diet, risk factors, food handling, adult, aged, middle aged, female, male, united kingdom, food, processed, uk biobank
10 authors
From CN
- Yue LiHuazhong University of Science and Technology
- Yuwei LaiHuazhong University of Science and Technology
- Tingting GengFudan University; Huazhong University of Science and Technology
- Peng‐Fei XiaHuazhong University of Science and Technology
- Jun‐Xiang ChenHuazhong University of Science and Technology
- Zhou‐Zheng TuHuazhong University of Science and Technology
Abstract
Scope
Among patients with diabetes, who have modified nutritional behavior and a higher risk of cardiovascular disease (CVD), the influence of ultraprocessed foods (UPFs) on CVD remains unknown. The study aims to evaluate the association between UPF intake and the risk of CVD among individuals with type 2 diabetes (T2D) and further examine the potential biological pathways linking the association.
Methods and results
This study includes 5405 participants with T2D who provided at least one 24-h dietary recall from the UK Biobank study. In the fully adjusted models, a 10% increase in the proportion of UPFs is associated with higher hazards of overall CVD (hazard ratio [HR]: 1.10; 95% confidence interval [CI]: 1.04, 1.15), coronary heart disease (HR: 1.10; 95% CI: 1.04, 1.16), heart failure (HR: 1.14; 95% CI: 1.05, 1.25), but not stroke (HR: 1.01; 95% CI: 0.90, 1.12). Cystatin C, high-density lipoprotein cholesterol (HDL-C), apolipoprotein A, C-reactive protein, and body mass index collectively explain 26.9% (12.8%, 48.5%) of the association between UPF intake and the risk of overall CVD.
Conclusion
Higher UPF intakes are associated with increased hazards of CVD among individuals with T2D, and the association is partly mediated through worsening biomarkers of renal function, lipid metabolism, inflammation, and body weight.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.