Adding a Leafy Vegetable Fraction to Diets Decreases the Risk of Red Meat Mortality in MASLD Subjects: Results from the MICOL Cohort
Donghia R, Tatoli R, Campanella A, Cuccaro F, Bonfiglio C, Giannelli G
Nutrients · 7 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- Ministero della Salute
- Government
- Italian Ministry of Health
- Government
- Italian Ministry of Health with Ricerca Corrente
- Grants
- Ministero della Salute (RicercaCorrente2023)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-04-18 · Nutrients · vol. 16 · issue 8 · p. 1207
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 8 citations · more than 88% of similar papers · 2.1× the field average
- References
- 56 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Liver Disease Diagnosis and Treatment · Nutritional Studies and Diet · Nuts composition and effects
- Keywords
- Leafy vegetables, Cohort, Food science, Red meat, Biology, Medicine, Internal medicine
- MeSH
- humans, vegetables, diet, risk factors, cohort studies, adult, aged, middle aged, female, male, non-alcoholic fatty liver disease, red meat
6 authors
From IT
- Rossella Donghia · correspondingGastroenterology Hospital "Saverio de Bellis"
- Rossella TatoliGastroenterology Hospital "Saverio de Bellis"
- Angelo CampanellaGastroenterology Hospital "Saverio de Bellis"
- Francesco Cuccaro
- Caterina BonfiglioGastroenterology Hospital "Saverio de Bellis"
- Gianluigi GiannelliGastroenterology Hospital "Saverio de Bellis"
Abstract
Background
Dietary guidelines recommend limiting red meat intake because it has been amply associated with increased cancer mortality, particularly in patients with liver conditions, such as metabolic dysfunction-associated fatty liver disease (MASLD). MASLD is the leading cause of liver dysfunction in the world today, and no specific treatment other than lifestyle correction has yet been established. The aim of this study was to explore the protective role of leafy vegetables when associated with high red meat consumption.
Methods
The study cohort included 1646 participants assessed during the fourth recall of the MICOL study, subdivided into two groups based on red meat intake (≤50 g/die vs. >50 g/die), in order to conduct a cancer mortality analysis. The prevalence of subjects that consumed >50 g/die was only 15.73%. Leafy vegetable intake was categorized based on median g/die consumption, and it was combined with red meat intake.
Conclusions
This is the first study to demonstrate that the consumption of about 30 g/die of leafy vegetables reduces the risk of mortality. A strong association with mortality was observed in subjects with MASLD, and the protective role of vegetables was demonstrated.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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