Safety of repeated low-level red-light therapy for children with myopia
Zhu M, Liu Y, Fang D, Li M, Fu T, Yao K, Wang P, Sun X, Xiang Y
Photodiagnosis and photodynamic therapy · 22 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Natural Science Foundation of Hubei Province
- Grants
- National Natural Science Foundation of China (82000893); Natural Science Foundation of Hubei Province (2021CFB342)
Based on 2 listed funder(s).
Publication
- Published
- 2024-05-08 · Photodiagnosis Photodyn Ther · vol. 47 · p. 104198
- Publisher
- Elsevier BV
- Cited
- 29 citations · more than 98% of similar papers · 7.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 48 works
- Access
- Open access (journal) · CC-BY-NC-ND
- Research areas
- Ophthalmology and Visual Impairment Studies · Retinopathy of Prematurity Studies · Retinal Diseases and Treatments
- Keywords
- Light therapy, Red light, Medicine, Optometry, Internal medicine, Biology
- MeSH
- humans, myopia, tomography, optical coherence, electroretinography, contrast sensitivity, child, female, male, low-level light therapy
9 authors
From CN, HK
- Mengxia ZhuTongji Hospital; Huazhong University of Science and Technology
- Ying LiuTongji Hospital; Huazhong University of Science and Technology
- Dengqin FangTongji Hospital; Huazhong University of Science and Technology
- Mu LiUnion Hospital; Huazhong University of Science and Technology
- Ting FuTongji Hospital; Huazhong University of Science and Technology
- KeJun YaoTongji Hospital; Huazhong University of Science and Technology
Abstract
Backgroud
To investigate the safety of repetitive low-level red-light therapy (RLRLT) in children with myopia.
Methods
Children with myopia were assigned to the RLRL and control groups. Axial length (AL) and spherical equivalent refraction (SER) were followed up at 3-, 6-, and 12-month. To evaluate the safety of RLRLT, at 6 and 12 months in the RLRL group, multifocal electroretinography (mfERG) and contrast sensitivity were recorded. Furthermore, optical coherence tomography was used to measure the relative reflectance of the ellipsoid zone (rEZR), photoreceptor outer segment (rPOSR), and retinal pigment epithelium (rRPER).
Results
A total of 108 children completed the trial (55 in the RLRL group and 53 in the control group). After 3, 6, and 12 months, AL was shorter and SER less myopic in the RLRL group than in the control group. Regarding the safety of the RLRLT, the response density and amplitude of the P1 wave of the first ring of the mfERG increased significantly at 6 months (P = 0.001 and P = 0.017, respectively). At 6 and 12 months, contrast sensitivity at the high spatial frequency increased. Moreover, the rEZR increased significantly at 6 months (P = 0.029), the rPOSR increased significantly at 6 and 12 months (both P < 0.001), and the increase in rPOSR was greater with greater AL regression.
Conclusions
Based on retinal function and structure follow-up, RLRLT was safe within 12 months. However, rEZR and rPOSR increased, the effects of this phenomenon requires further observation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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