The Effect of Physical Activity and Repeated Whole-Body Cryotherapy on the Expression of Modulators of the Inflammatory Response in Mononuclear Blood Cells among Young Men
Kusmierczyk J, Wiecek M, Wojciak G, Mardyła M, Kreiner G, Szygula Z, Szymura J
Journal of clinical medicine · 4 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- Ministry of Science and Higher Education
- Government
- Minister of Science’s program
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-05-06 · J Clin Med · vol. 13 · issue 9 · p. 2724
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 5 citations · more than 75% of similar papers · 0.9× the field average
- References
- 55 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Exercise and Physiological Responses · Fibromyalgia and Chronic Fatigue Syndrome Research · Thermoregulation and physiological responses
- Keywords
- Medicine, SOD2, Cryotherapy, Inflammation, Peripheral blood mononuclear cell, Oxidative stress, White blood cell, Internal medicine, Immunology, Superoxide dismutase, Surgery
7 authors
From PL
- Justyna Kuśmierczyk · correspondingUniversity of Physical Culture in Kraków
- Magdalena WięcekUniversity of Physical Culture in Kraków
- Gabriela WojciakAndrzej Frycz Modrzewski Krakow University
- Mateusz MardyłaUniversity of Physical Culture in Kraków
- Grzegorz KreinerMaj Institute of Pharmacology; Polish Academy of Sciences
- Zbigniew SzygułaUniversity of Physical Culture in Kraków
Abstract
Background: Series of whole-body cryotherapy (WBC) among healthy and physically active individuals can potentially reduce inflammatory response, although exact mechanisms remain unclear. Methods: The impact of whole-body cryotherapy on inflammation modulators among 28 young males, categorized as non-training (NTR, N = 10), non-training with WBC (NTR-WBC, N = 10), and training with WBC (TR-WBC, N = 8), is investigated in this study. Over a period of eight weeks, NTR-WBC and TR-WBC subjects underwent 24 WBC treatments (-130 °C for 3 min, three times a week), examining changes in mRNA expressions of IL-1A, IL-6, IL-10, IFN-G, SIRT1, SIRT3, SOD2, GSS, and ICAM-1. Results: The received data indicate an acute inflammatory response to initial WBC (increased IL-1A, IL-6, and SIRT), with a greater effect in NTR-WBC. Subsequent sessions showed enhanced expressions of antioxidative genes in both WBC groups, particularly non-trained, suggesting improved oxidative stress adaptation. A notable decrease in ICAM-1 mRNA post-24 WBC treatments in NTR-WBC signifies a potential systemic anti-inflammatory effect. Conclusions: The findings of the study suggest that the combination of regular physical activity with WBC administered three times per week can potentially modulate inflammatory and antioxidant responses. This modulation is evidenced by changes in the expression of genes related to these processes.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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