Funded in part by Natreon (United States), Natreon Inc.
Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial
Pandit S, Srivastav AK, Sur TK, Chaudhuri S, Wang Y, Biswas TK
Nutrients · 25 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Government
- Indian Council of Medical Research
- Company
- Natreon (United States)
- Company
- Natreon Inc.
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2024-04-26 · Nutrients · vol. 16 · issue 9 · p. 1293
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 45 citations · more than 100% of similar papers · 22.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 27 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Phytochemicals and Medicinal Plants · Mindfulness and Compassion Interventions · Hallucinations in medical conditions
- Keywords
- Withania somnifera, Medicine, Placebo, Randomized controlled trial, Chronic stress, Phytotherapy, Internal medicine, Traditional medicine, Pathology
- MeSH
- pituitary-adrenal system, hypothalamo-hypophyseal system, humans, withania, plant leaves, plant roots, chronic disease, plant extracts, medicine, ayurvedic, phytotherapy, double-blind method, stress, psychological, adult, middle aged, female, male, young adult
6 authors
From IN, US
- Srikanta PanditGovernment of West Bengal
- Amit Kumar SrivastavGovernment of West Bengal
- Tapas Kumar SurGovernment of West Bengal
- Supriyo ChaudhuriGovernment of West Bengal
- Yan WangUniversity of California, Los Angeles
- Tuhin Kanti Biswas · correspondingGovernment of West Bengal
Abstract
Background
Stress is a known causative factor in modulating cognitive health, which overall well-being and quality of life are dependent on. Long-term stress has been shown to disrupt the balance of the hypothalamic-pituitary-adrenal (HPA) axis. Adaptogens, such as Withania somnifera (ashwagandha), are commonly used in Ayurvedic medicine for stress relief and ameliorating HPA-axis dysfunction. The aim of this study was to support the role of a root and leaf water-extracted ashwagandha extract (WS) in stress reduction by confirming the lowest clinically validated dose for stress management (125 mg/day) in a dose-dependent clinical study in adults with self-reported high stress.
Methods
An 8-week, randomized, double-blinded, placebo-controlled study to compare the effects of three different WS extract doses (125, 250 and 500 mg) was performed. A total of 131 adults were enrolled, and 98 were included in the final analysis. Attenuation of chronic stress was measured using the 14-item Perceived Stress Scale (PSS) and biochemical-related stress parameters.
Results
We have shown that aqueous WS extract (roots and leaves) safely reduces mild to moderate chronic stress at doses of 125 mg, 250 mg, and 500 mg/day for 8 weeks.
Conclusions
Our findings demonstrate the stress-reduction capabilities of this well-characterized aqueous extract of WS (root and leaf) at the low dose of 125 mg/day, in a dose-dependent manner, via the modulation of the HPA axis.
Trial registration
This study was registered with the Clinical Trials Registry-India (CTRI) with the registration number: CTRI/2019/11/022100.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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