Effects of dietary nitrate supplementation on oral health and associated markers of systemic health: a systematic review
Alhulaefi SS, Watson AW, Ramsay SE, Jakubovics NS, Matu J, Griffiths A, Kimble R, Siervo M, Brandt K, Shannon OM
Critical reviews in food science and nutrition · 11 citations
How it was studied
- Design
- Systematic review (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- University or hospital
- Taif University
- University or hospital
- Taif University, Taif, KSA
Based on 2 listed funder(s).
Publication
- Published
- 2024-05-11 · Crit Rev Food Sci Nutr · vol. 65 · issue 14 · pp. 2813–2828
- Publisher
- Taylor & Francis
- Cited
- 13 citations · more than 80% of similar papers · 1.8× the field average
- References
- 58 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Oral microbiology and periodontitis research · Salivary Gland Disorders and Functions · Dental Erosion and Treatment
- Keywords
- Medicine, Nitrate, CINAHL, Cochrane Library, Oral Microbiome, Randomized controlled trial, Saliva, Meta-analysis, Systematic review, Physiology, Environmental health, Food science, MEDLINE, Internal medicine, Psychological intervention, Biology, Disease, Biochemistry
- MeSH
- saliva, humans, beta vulgaris, gingivitis, nitrates, diet, hydrogen-ion concentration, dietary supplements, oral health, randomized controlled trials as topic, microbiota, biomarkers, fruit and vegetable juices
10 authors
From SA, BE, GB, RS, AU
- Shatha S. AlhulaefiTaif University; Nutrition Sciences (Belgium); Newcastle University
- Anthony WatsonNutrition Sciences (Belgium); Newcastle University
- Sheena E RamsayNewcastle University
- Nick S. JakubovicsNewcastle Dental Hospital; Newcastle University
- Jamie MatuLeeds Beckett University
- Alex GriffithsLeeds Beckett University
Abstract
Poor oral health can impact an individual's ability to eat and has been associated with an increased risk of non-communicable diseases. While the benefits of nitrate consumption on oral health were first proposed more than 20 years ago, no systematic review has been published examining effects of dietary nitrate on oral health. This systematic review investigated the effects of dietary nitrate on markers of oral health in vivo in randomized controlled trials (RCTs). Five databases (PubMed, The Cochrane Library, CINAHL, MEDLINE, and SPORTDiscus) were searched from inception until March 2023. Nine articles reporting data on 284 participants were included. Dietary nitrate was provided via beetroot juice in most studies. The duration of the interventions ranged from one day to six weeks. Dietary nitrate supplementation increased the relative abundance of several individual bacterial genera including Neisseria and Rothia. Dietary nitrate supplementation increased salivary pH and decreased salivary acidification following consumption of a sugar-sweetened beverage. Furthermore, dietary nitrate supplementation resulted in a decrease in the gingival inflammation index. The results of this systematic review suggest that dietary nitrate could represent a potential nutritional strategy to positively modify oral health by impacting the oral microbiome, altering salivary pH, and minimizing gingival inflammation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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